Appropriate Use of Interferon Beta-1a in Multiple Sclerosis

被引：0
作者：
Lawrence Jacobs
Carol M. Brownscheidle
机构：
[1] State University of New York at Buffalo,Department of Neurology, Buffalo General Hospital, and William C. Baird Multiple Sclerosis Research Center, Millard Fillmore Hospital
[2] Buffalo General Hospital,Department of Neurology
来源：
BioDrugs | 1999年 / 11卷
关键词：
Multiple Sclerosis; Adis International Limited; Multiple Sclerosis Patient; Expand Disability Status Scale; Interferon Beta;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous system, is the most common crippling neurological disease of young adults in the US. The 2 basic clinical forms of the disease (relapsing and progressive), which can occur singly or in combination, encompass a wide range of clinical severities are usually established between 18 and 35 years of age and can persist an entire lifetime. Life expectancy of 20 years is 85% of normal.
引用
收藏
页码：155 / 163
页数：8
相关论文
共 80 条
[1]  
Hohlfeld R.(1997)Biotechnological agents for the immunotherapy of multiple sclerosis. Principles, problems and perspectives Brain 120 865-916
[2]  
Dhib-Jalbut S.(1990)Immunology of multiple sclerosis Ann Allergy 64 433-44
[3]  
McFarlin D.E.(1989)Multiple sclerosis: an overview Biomed Pharmacother 43 335-46
[4]  
Julien J.(1998)Axonal transection in the lesions of multiple sclerosis N Engl J Med 338 278-85
[5]  
Ferrer X.(1995)Immunotherapy in multiple sclerosis Pt 1. Am J Health Syst Pharm 52 1985-2000
[6]  
Traggs B.D.(1993)Immune-mediated demyelination Ann Neurol 33 563-7
[7]  
Peterson J.(1996)Distinct patterns of multiple sclerosis pathology indicates heterogeneity in pathogenesis [review] Brain Pathol 6 259-74
[8]  
Rarnsohoff R.M.(1993)Dominance and crypticity of T cell antigenic determinants [review] Annu Rev Immunol 11 729-66
[9]  
Becker C.C.(1995)Evolution of the T-cell repertoire during the course of experimental immune-mediated demyelinating diseases [review] Immunol Rev 144 225-44
[10]  
Gidal B.E.(1995)Antibody facilitation of multiple sclerosis-like lesions in a nonhuman primate J Clin Invest 96 2966-74
12345678