Influence of miRNA Gene Polymorphism on Recurrence and Age at Onset of Ischemic Stroke in a Chinese Han Population

被引:0
作者
Xu Liu
Qianwen Wang
Ruixia Zhu
机构
[1] The First Affiliated Hospital of China Medical University,Department of Neurology
来源
Neurotoxicity Research | 2020年 / 37卷
关键词
Ischemic stroke; miRNA; Polymorphism; Recurrence;
D O I
暂无
中图分类号
学科分类号
摘要
Polymorphisms in microRNAs (miRNAs) are associated with ischemic stroke occurrence and traditional risk factors for ischemic stroke such as atherosclerosis, hypertension, hyperlipidemia, and diabetes. However, few studies have examined recurrent ischemic stroke as an outcome. Thus, the aim of our study was to examine association of miRNA gene polymorphisms (namely, miR-126 rs4636297, miR-149 rs2292832, miR-124 rs531564, miR-499 rs3746444, miR-143 rs12655723, and miR-122 rs17669) with recurrence of ischemic stroke. miRNA gene polymorphisms were genotyped using the polymerase chain reaction–ligation detection reaction (PCR–LDR) method in 657 patients with ischemic stroke. Association of miRNA polymorphisms with prognosis outcomes was examined by the Kaplan–Meier method, log-rank test, and Cox proportional hazards models. miR-122 rs17669 was significantly associated with recurrence risk of ischemic stroke under the recessive model. Cox regression analysis showed that the CC genotype of rs17669 was associated with an increased risk of 1.9-fold for stroke recurrence (hazard ratio = 1.879; 95% confidence interval = 1.182–2.985; P = 0.008). Further, this effect was more evident among the non-drinker and male subgroups. We found no difference in risk of recurrent ischemic stroke among the other five miRNA polymorphisms. Furthermore, we identified a significant association between the miR-149 rs2292832 polymorphism and age at onset of first-ever stroke. Altogether, miR-122 rs17669 is a significant predictor for the risk of recurrent stroke, independent of traditional risk factors.
引用
收藏
页码:781 / 787
页数:6
相关论文
共 50 条
[41]   CYP4F2 gene V433M polymorphism is associated with ischemic stroke in the male Northern Chinese Han population [J].
Deng, Shumin ;
Zhu, Gang ;
Liu, Fang ;
Zhang, Hui ;
Qin, Xue ;
Li, Lei ;
He Zhiyi .
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2010, 34 (04) :664-668
[42]   Association between HMGB1 genetic variants and ischemic stroke susceptibility, onset age, and recurrence risk among Chinese Han individuals [J].
Qiu, Luying ;
Li, Long ;
He, Zhiyi ;
Liu, Fang ;
Deng, Shumin ;
Wang, Yanzhe .
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2023, 15 (05) :3326-3341
[43]   Genetic Variation of Inflammatory Genes to Ischemic Stroke Risk in a Chinese Han Population [J].
Zhang, Zhongqiu ;
Mei, Yanping ;
Xiong, Mengqiu ;
Lu, Fang ;
Zhao, Xianghong ;
Zhu, Junrong ;
He, Bangshun .
PHARMACOGENOMICS & PERSONALIZED MEDICINE, 2021, 14 :977-986
[44]   A Novel Risk Haplotype of ALOX5AP Gene is Associated with Ischemic Stroke in Chinese Han Population [J].
Yang, Dongzhi ;
He, Ying ;
Li, Manyu ;
Shi, Congcong ;
Song, Guoying ;
Wang, Qing ;
Fan, Yujia ;
Feng, Qingchuan ;
Zheng, Hong .
JOURNAL OF MOLECULAR NEUROSCIENCE, 2014, 53 (03) :493-499
[45]   A Novel Risk Haplotype of ALOX5AP Gene is Associated with Ischemic Stroke in Chinese Han Population [J].
Dongzhi Yang ;
Ying He ;
Manyu Li ;
Congcong Shi ;
Guoying Song ;
Qing Wang ;
Yujia Fan ;
Qingchuan Feng ;
Hong Zheng .
Journal of Molecular Neuroscience, 2014, 53 :493-499
[46]   Association of inflammatory response gene polymorphism with atherothrombotic stroke in Northern Han Chinese [J].
Zhao, Jiuhan ;
Wang, Xiaohong ;
Xu, Jialiang ;
Li, Nan ;
Shang, Xiuli ;
He, Zhiyi ;
Yang, Jun .
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2012, 44 (12) :1023-1030
[47]   Genetic Polymorphism of NQO1 Gene is Associated with Susceptibility of Ischemic Stroke in Chinese Han Nationality [J].
Yan, Limin ;
Xu, Dedong ;
Xiao, Ying ;
Dai, Mingming ;
Wang, Ting ;
Zhuang, Xinhong ;
Wu, Kunliang .
NEUROPSYCHIATRIC DISEASE AND TREATMENT, 2022, 18 :2211-2217
[48]   Genetic polymorphisms in the ALDH2 gene and the risk of ischemic stroke in a Chinese han population [J].
Sun, Shuaiqi ;
He, Jun ;
Zhang, Yao ;
Xiao, Rongjun ;
Yan, Mengdan ;
Ren, Yulin ;
Zhu, Yuanyuan ;
Jin, Tianbo ;
Xia, Ying .
ONCOTARGET, 2017, 8 (60) :101936-101943
[49]   The Association Between Thymidylate Synthase Gene Polymorphisms and the Risk of Ischemic Stroke in Chinese Han Population [J].
Fuhua Yu ;
Lei Shi ;
Qianru Wang ;
Xiaohui Xing ;
Zhongchen Li ;
Lei Hou ;
Zhengshan Zhou ;
Zengguang Wang ;
Yilei Xiao .
Biochemical Genetics, 2024, 62 :468-484
[50]   The Association Between Thymidylate Synthase Gene Polymorphisms and the Risk of Ischemic Stroke in Chinese Han Population [J].
Yu, Fuhua ;
Shi, Lei ;
Wang, Qianru ;
Xing, Xiaohui ;
Li, Zhongchen ;
Hou, Lei ;
Zhou, Zhengshan ;
Wang, Zengguang ;
Xiao, Yilei .
BIOCHEMICAL GENETICS, 2024, 62 (01) :468-484