Disseminated Infection due to Nocardia transvalensis Coincident with Cryptococcus neoformans variety gattii Meningitis

被引：0
|
作者：
J. R. Dyer
N. Ketheesan
R. E. Norton
C. I. J. Ashhurst-Smith
P. Keary
J. T. La Brooy
机构：
[1] Infectious Diseases Unit,
[2] St. Andrew's Hospital,undefined
[3] PO Box 839,undefined
[4] Ipswich 4305,undefined
[5] Queensland,undefined
[6] Australia e-mail: jdyer@medeserv.com.au,undefined
[7] Infectious Diseases Unit,undefined
[8] Townsville General Hospital,undefined
[9] Townsville 4810,undefined
[10] Queensland,undefined
[11] Australia,undefined
[12] Department of Medicine,undefined
[13] North Queensland Clinical School,undefined
[14] University of Queensland,undefined
[15] PO Box 480,undefined
[16] Townsville 4810,undefined
[17] Queensland,undefined
[18] Australia,undefined
[19] Department of Microbiology,undefined
[20] Townsville General Hospital,undefined
[21] Townsville 4810,undefined
[22] Queensland,undefined
[23] Australia,undefined
[24] Department of General Medicine,undefined
[25] Townsville General Hospital,undefined
[26] Townsville 4810,undefined
[27] Queensland,undefined
[28] Australia,undefined
来源：
European Journal of Clinical Microbiology and Infectious Diseases | 1999年 / 18卷
关键词：
Meningitis; Treatment Response; Antimicrobial Therapy; Lymphocyte Proliferation; Cryptococcus Neoformans;
D O I：
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学科分类号：
摘要：
 A case of meningitis due to Cryptococcus neoformans var. gattii coincident with disseminated Nocardia transvalensis infection is reported. Nocardia infection initially progressed despite high-dose antimicrobial therapy. Although a specific immunologic defect could not be defined, in vitro lymphocyte proliferation in response to stimulation with the Nocardia isolate was reduced. It is proposed that coinfection with Cryptococcus neoformans may have contributed to the observed impairment of lymphocyte function, leading to disseminated Nocardia disease and a suboptimal treatment response.
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页码：587 / 590
页数：3
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