Skeletal involvement in Langerhans cell histiocytosis

被引：93

作者：

Khung S. ^{[1
,2
]}

Budzik J.-F. ^{[3
]}

Amzallag-Bellenger E. ^{[1
]}

Lambilliote A. ^{[4
]}

Soto Ares G. ^{[5
]}

Cotten A. ^{[2
]}

Boutry N. ^{[1
]}

机构：

[1] Department of Pediatric Radiology, Hôpital Jeanne de Flandre, Université de Lille 2, CHRU de Lille, Lille

[2] Department of Musculoskeletal Radiology, Hôpital Roger Salengro, Université de Lille 2, CHRU de Lille, Lille

[3] Department of Radiology, Hôpital Saint-Philibert, Groupe Hospitalier de l'Institut Catholique de Lille (GHICL), Lomme

[4] Department of Pediatric Hematology, Hôpital Jeanne de Flandre, Université de Lille 2, CHRU de Lille, Lille

[5] Department of Neuroradiology, Hôpital Roger Salengro, Université de Lille 2, CHRU de Lille, Lille

来源：

Insights into Imaging | 2013年 / 4卷 / 5期

关键词：

Children; Diagnostic imaging; Langerhans cell histiocytosis; Magnetic resonance imaging; Radiography; Spiral computed; Tomography;

D O I：

10.1007/s13244-013-0271-7

中图分类号：

学科分类号：

摘要：

Langerhans cell histiocytosis (LCH) represents a disorder characterised by an abnormal accumulation of histiocytes in miscellaneous tissues. The bone is commonly affected, especially the flat bones, the spine and the long bones. Some lesions in children such as a "vertebra plana" or a solitary lytic lesion of the skull may be suggestive for LCH, whereas others can be confused with a malignant tumour or osteomyelitis. This pictorial essay presents the main usual and unusual skeletal manifestations observed in LCH. Teaching points • Osseous involvement in children with LCH is very similar to that seen in multiple myeloma. • A solitary lytic lesion of the cranial vault is a typical radiographic finding of LCH. • A vertebra plana appearance in the spine is another typical radiographic finding. • Extensive signal intensity changes within bone marrow on MRI are a helpful sign for the diagnosis. • In long bones, endosteal scalloping may be responsible for a "budding appearance". © 2013 The Author(s).

引用

页码：569 / 579

页数：10

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