Emodin ameliorates cisplatin-induced apoptosis of rat renal tubular cells in vitro by activating autophagy

被引:0
作者
Hong Liu
Liu-bao Gu
Yue Tu
Hao Hu
Yan-ru Huang
Wei Sun
机构
[1] The Affiliated Hospital of Nanjing University of Chinese Medicine,Department of Nephrology
[2] Nanjing University of Chinese Medicine,Department of Graduate School
[3] Center for Diabetes Care,Department of Molecular Signaling
[4] Education and Research,undefined
[5] Jiangsu Province Institute of Geriatrics,undefined
[6] Interdisciplinary Graduate School of Medicine and Engineering,undefined
[7] University of Yamanashi,undefined
来源
Acta Pharmacologica Sinica | 2016年 / 37卷
关键词
cisplatin; nephrotoxicity; apoptosis; rat renal tubular cells; emodin; autophagy; bafilomycin A1; rapamycin; AMPK; mTOR; compound C;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:235 / 245
页数:10
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  • [21] Kato N(2009)LKB1 and AMP-activated protein kinase control of mTOR signalling and growth Acta Physiol 196 65-54
  • [22] Mizushima N(2013)Intervention in genotoxic stress-induced senescence by cordycepin through activation of eIF2alpha and suppression of Sp1 Toxicol Sci 134 345-200
  • [23] Periyasamy-Thandavan S(2013)Abrogation of cisplatin-induced nephrotoxicity by emodin in rats Fundam Clin Pharmacol 27 192-18
  • [24] Jiang M(2004)LC3 conjugation system in mammalian autophagy Int J Biochem Cell Biol 36 2503-26
  • [25] Wei Q(2010)Methods in mammalian autophagy research Cell 140 313-93
  • [26] Smith R(2009)Regulation mechanisms and signaling pathways of autophagy Annu Rev Genet 43 67-9
  • [27] Yin XM(1997)Experimental treatment of rhubarb on mesangio-proliferative glomerulonephritis in rats Zhonghua Nei Ke Za Zhi 36 87-80
  • [28] Dong Z(2003)Inhibitory effect of emodin on WI-38 cell apoptosis induced by cisplatin Chin J Pharmacol Toxicol 17 276-8
  • [29] Yang C(2011)Emodin potentiates the anticancer effect of cisplatin on gallbladder cancer cells through the generation of reactive oxygen species and the inhibition of survivin expression Oncol Rep 26 1143-75
  • [30] Kaushal V(2008)Autophagy fights disease through cellular self-digestion Nature 451 1069-52