Interleukin-6, but Not Soluble Adhesion Molecules, Predicts a Subsequent Mortality from Cardiovascular Disease in Patients with Acute ST-Segment Elevation Myocardial Infarction

被引:0
作者
Zhen-Xing Fan
Qi Hua
Yin-Ping Li
Rong-Kun Liu
Zheng Yang
机构
[1] Capital Medical University,Department of Cardiology, Xuanwu Hospital
[2] Capital Medical University,Department of Emergency, Xuanwu Hospital
来源
Cell Biochemistry and Biophysics | 2011年 / 61卷
关键词
Acute ST-segment elevation myocardial infarction; Interleukin-6; Soluble intercellular adhesion molecule-1; Soluble vascular cell adhesion molecule-1; Soluble P-selectin; Cardiovascular mortality;
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摘要
Inflammatory responses are an important element in the atherosclerotic process. Therefore, inflammatory markers can potentially serve as predictors of cardiovascular risk. However, the existing data are limited and controversial. We conducted a prospective cohort study with 263 patients with first acute ST-segment elevation myocardial infarction (STEMI) who were admitted to our Hospital within 6 h after the symptoms onset. Clinical data were recorded and serum admission levels of interleukin-6 (IL-6), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and soluble P-selectin (sP-selectin) were determined. The patients were then followed up for 3 years to document cardiovascular mortality. During the follow-up, 34 patients died from cardiovascular causes. The admission levels of IL-6 were significantly higher in these patients, whereas sICAM-1, sVCAM-1, and sP-selectin were comparable between these and the survived patients. The Kaplan–Meier plots revealed a significant increase in cardiovascular mortality with increasing levels of IL-6 (P = 0.0002, χ2 test). The logistic regression analysis indicated that IL-6 was an independent predictor for cardiovascular mortality. To conclude, our findings indicate that elevated admission levels of IL-6, but not soluble adhesion molecules, provide valuable information for risk assessment of long-term cardiovascular mortality in patients with STEMI.
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页码:443 / 448
页数:5
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