Fatal outcome in a child after ingestion of a transdermal fentanyl patch

被引：0
作者：
Jörg Teske
Jens-Peter Weller
Klaus Larsch
Hans Dieter Tröger
Matthias Karst
机构：
[1] Hannover Medical School,Institute of Legal Medicine
[2] Hannover Medical School,Department of Anesthesiology, Pain Clinic
来源：
International Journal of Legal Medicine | 2007年 / 121卷
关键词：
Fatal intoxication; Transdermal fentanyl patch; Fentanyl; Norfentanyl; LC–MS–MS;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The case history and toxicological findings of a fatal fentanyl intoxication due to ingestion of a transdermal patch are presented. A 1-year-old otherwise healthy girl was put to bed and 2 h later she was found dead. The autopsy revealed a 25-μg/h (4.2 mg) transdermal fentanyl patch in the stomach. Toxicological analysis by liquid chromatography–tandem mass spectrometry with positive electrospray ionization yielded fentanyl and norfentanyl concentrations in the peripheral blood of 5.6 and 5.9 ng/ml, heart blood 19.0 and 8.9 ng/ml, and liver 235 and 26 ng/g, respectively. The cause of death was determined to be a fentanyl overdose. The investigation established that the child has unintentionally swallowed the patch, which had been lying on the floor.
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