Biodistribution and toxicity of intravenously administered silica nanoparticles in mice

被引:0
|
作者
Guangping Xie
Jiao Sun
Gaoren Zhong
Liyi Shi
Dawei Zhang
机构
[1] Shanghai Ninth People’s Hospital,Shanghai Biomaterials Research & Testing Center
[2] Shanghai Jiaotong University School of Medicine,School of Pharmacy
[3] Fudan University,Nano
[4] Shanghai University,Science & Technology Research Center
来源
Archives of Toxicology | 2010年 / 84卷
关键词
Tissue distribution; Nanotoxicity; Silica nanoparticles; Quantitative; Endocytosis;
D O I
暂无
中图分类号
学科分类号
摘要
As the biosafety of nanotechnology becomes a growing concern, the in vivo nanotoxicity of NPs has drawn a lot of attention. Silica nanoparticles (SiNPs) have been widely developed for biomedical use, but their biodistribution and toxicology have not been investigated extensively in vivo. Although investigations of in vivo qualitative distribution of SiNPs have been reported, the time-dependent and quantitative informations about the distribution of SiNPs are still lacking. Here we investigated the long-term (30 days) quantitative tissue distribution, and subcellular distribution, as well as potential toxicity of two sizes of intravenously administered SiNPs in mice using radiolabeling, radioactive counting, transmission electron microscopy and histological analysis. The results indicated that SiNPs accumulate mainly in lungs, liver and spleen and are retained for over 30 days in the tissues because of the endocytosis by macrophages, and could potentially cause liver injury when intravenously injected.
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页码:183 / 190
页数:7
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