Micronization of curcumin with biodegradable polymer by supercritical anti-solvent using micro swirl mixer

被引：0
作者：
Kimthet Chhouk
Hideki Wahyudiono
Shin-Ichro Kanda
Motonobu Kawasaki
机构：
[1] Nagoya University,Department of Chemical Engineering
[2] Institute of Technology of Cambodia,Department of Chemical Engineering and Food Technology
[3] Nagoya University,Department of Materials Process Engineering
[4] National Institute of Advanced Industrial Science and Technology,Research Institute for Chemical Engineering Process Technology
来源：
Frontiers of Chemical Science and Engineering | 2018年 / 12卷
关键词：
micronization; curcumin; polyvinylpyrrolidone; supercritical anti-solvent; swirl mixer;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Curcumin is a hydrophobic polyphenol compound exhibiting a wide range of biological activities such as anti-inflammatory, anti-bacterial, anti-fungal, anti-carcinogenic, anti-human immunodeficiency virus, and antimicrobial activity. In this work, a swirl mixer was employed to produce the micronized curcumin with polyvinylpyrrolidone (PVP) by the supercritical anti-solvent process to improve the bioavailability of curcumin. The effects of operating parameters such as curcumin/PVP ratio, feed concentration, temperature, pressure, and CO2 flow rate were investigated. The characterization and solubility of particles were determined by using scanning electron microscopy, Fourier Transform Infrared spectroscopy, and ultra-violet-visible spectroscopy. The result shows that the optimal condition for the production of curcumin/PVP particles is at curcumin/PVP ratio of 1:30, feed concentration of 5 mg·mL−1, temperature of 40 °C, pressure of 15 MPa, and CO2 flow rate of 15 mL·min−1. Moreover, the dissolution of curcumin/PVP particles is faster than that of raw curcumin.
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页码：184 / 193
页数：9
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