Growth hormone-inhibiting activity of cortistatin in the rat

被引：0
作者：
R. Deghenghi
R. Avallone
A. Torsello
G. Muccioli
E. Ghigo
Vittorio Locatelli
机构：
[1] Europeptides,Department of Experimental and Environmental Medicine and Biotechnologies
[2] University of Milano-Bicocca,Departments of Anatomy, Pharmacology and Forensic Medicine
[3] University of Turin,Internal Medicine
[4] University of Turin,Vittorio Locatelli, Dipartimento di Farmacologia
[5] Università di Milano,undefined
来源：
Journal of Endocrinological Investigation | 2001年 / 24卷
关键词：
Cortistatin; somatostatin; growth hormone; pituitary receptors; growth hormone secretagogues;
D O I：
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摘要：
Cortistatin-14 (CST-14) is an endogenous neuropeptide with notable structural similarities to native somatostatin-14 (SS-14), but different physiological functions. Differences in the physiology of the two peptides do not provide conclusive evidence for a specific receptor for CST. To date, the effects of CST-14 on anterior pituitary hormones have never been reported. Aim of this study was to investigate the in vivo effects of CST-14 on GH secretion in comparison to SS-14. Our results demonstrate that CST-14 was very effective in reducing GH secretion in normal male anaesthetized rats. Its activity was similar to that of SS-14 and had a rapid onset and a slightly longer duration of action. In conclusion, we have reported for the first time that CST is a potent and effective inhibitor of GH release in rats and that its action may be mediated by the interaction with one or different SS receptor subtypes.
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页码：RC31 / RC33
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