Molecular biology of gliomas

被引：31

作者：

Lassman A.B. ^{[1
]}

机构：

[1] Department of Neurology, Memorial Sloan-Kettering Cancer Ctr., New York, NY 10021

来源：

Current Neurology and Neuroscience Reports | 2004年 / 4卷 / 3期

关键词：

Epidermal Growth Factor Receptor; Astrocytoma; Receptor Tyrosine Kinase; Glioblastoma Multiforme; Epidermal Growth Factor Receptor Mutation;

D O I：

10.1007/s11910-004-0043-3

中图分类号：

学科分类号：

摘要：

Gliomas are the most common primary neoplasm of the brain. Unfortunately, they are often refractory to treatment and portend a poor prognosis. However, recent discoveries have shed light on the molecular events driving glioma growth, including abnormalities of three major molecular pathways: extracellular growth factors and their receptors (eg, EGF/EGFR and PDGF/PDGFR), signal transduction cascades (eg, RAS and AKT), and cell proliferation controls (eg, INK4A-ARF). Each of these abnormalities is described in detail. Efforts to inhibit abnormally activated pathways are underway through multi-institutional clinical trials. Copyright © 2004 by Current Science Inc.

引用

页码：228 / 233

页数：5

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