Between- and Within-Individual Sociodemographic and Psychological Determinants of PrEP Adherence Among Men Who have Sex with Men Prescribed a Daily PrEP Regimen in Wales

被引：0
作者：
David Gillespie
Marijn de Bruin
Dyfrig A. Hughes
Richard Ma
Adam Williams
Fiona Wood
Zoë Couzens
Adam Jones
Kerenza Hood
机构：
[1] Cardiff University,Centre for Trials Research, College of Biomedical & Life Sciences, School of Medicine
[2] Radboud University Medical Center,Centre for Health Economics and Medicines Evaluation
[3] Institute of Health Sciences,Division of Population Medicine and PRIME Centre Wales, College of Biomedical & Life Sciences, School of Medicine
[4] IQ Healthcare,Policy, Research and International Development
[5] Bangor University,undefined
[6] Imperial College London,undefined
[7] Cardiff University,undefined
[8] Public Health Wales NHS Trust,undefined
[9] Public Health Wales,undefined
来源：
AIDS and Behavior | 2023年 / 27卷
关键词：
HIV prevention; PrEP; Adherence; Determinants; MSM;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We investigated the determinants of daily PrEP use and coverage of condomless anal sex (CAS) by PrEP among men who have sex with men in Wales, UK. We measured PrEP use by electronic monitors and CAS by secure online surveys. We defined PrEP use based on daily medication cap openings and coverage as CAS episodes preceded by ≥ 3 days of PrEP use and followed by ≥ 2 days of PrEP use. We included 57 participants (5463 observations). An STI diagnosis was associated with lower PrEP use but also lower PrEP coverage. Older adults had higher PrEP use. A belief that other PrEP users took PrEP as prescribed was associated with lower PrEP coverage. An STI diagnosis is an important cue for an intervention, reflecting episodes of high-risk sexual behaviour and low PrEP coverage. Other results provide a basis for the development of an evidence-informed intervention for promoting coverage of PrEP.
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页码：1564 / 1572
页数：8
相关论文
共 74 条
  • [1] Grant RM(2010)Preexposure chemoprophylaxis for HIV prevention in men who have sex with men N Engl J Med 363 2587-2599
  • [2] Lama JR(2012)Antiretroviral prophylaxis for HIV prevention in heterosexual men and women N Engl J Med 367 399-410
  • [3] Anderson PL(2013)Antiretroviral prophylaxis for HIV infection in injecting drug users in Bangkok, Thailand (the Bangkok Tenofovir Study): a randomised, double-blind, placebo-controlled phase 3 trial Lancet 381 2083-2090
  • [4] Baeten JM(2017)Efficacy, safety, and effect on sexual behaviour of on-demand pre-exposure prophylaxis for HIV in men who have sex with men: an observational cohort study Lancet HIV 4 e402-e410
  • [5] Donnell D(2016)Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial Lancet 387 53-60
  • [6] Ndase P(2016)Current concepts for PrEP adherence in the PrEP revolution Curr Opin HIV AIDS 11 10-17
  • [7] Choopanya K(2008)Lack of effectiveness of cellulose sulfate gel for the prevention of vaginal HIV transmission N Engl J Med 359 463-472
  • [8] Martin M(2008)Effectiveness of cellulose sulfate vaginal gel for the prevention of HIV infection: results of a phase III trial in Nigeria PLoS ONE 3 1-14
  • [9] Suntharasamai P(2012)The meaning of adherence when behavioral risk patterns vary: obscured use- and method-effectiveness in HIV-prevention trials PLoS ONE 7 179-211
  • [10] Molina J-M(2018)A systematic review of adherence to oral pre-exposure prophylaxis for HIV—how can we improve uptake and adherence? BMC Infect Dis 18 1249-1265
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