Emerging role of RNA methyltransferase METTL3 in gastrointestinal cancer

被引：0
作者：
Qiang Wang
Wei Geng
Huimin Guo
Zhangding Wang
Kaiyue Xu
Chen Chen
Shouyu Wang
机构：
[1] The Affiliated Drum Tower Hospital of Nanjing University Medical School,Department of Hepatobiliary Surgery
[2] The Affiliated Yancheng No. 1 People’s Hospital of Nanjing University Medical School,Department of Gastroenterology
[3] The Affiliated Drum Tower Hospital of Nanjing University Medical School,Department of Radiotherapy
[4] The First Affiliated Hospital of Nanjing Medical University,Department of Molecular Cell Biology and Toxicology, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health
[5] Nanjing Medical University,Jiangsu Key Laboratory of Molecular Medicine
[6] Medical School of Nanjing University,Center for Public Health Research
[7] Medical School of Nanjing University,undefined
来源：
Journal of Hematology & Oncology | / 13卷
关键词：
Gastrointestinal cancer; Epigenetics; METTL3; Oncogene; m; A;
D O I：
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学科分类号：
摘要：
Gastrointestinal cancer, the most common solid tumor, has a poor prognosis. With the development of high-throughput sequencing and detection technology, recent studies have suggested that many chemical modifications of human RNA are involved in the development of human diseases, including cancer. m6A, the most abundant modification, was revealed to participate in a series of aspects of cancer progression. Recent evidence has shown that methyltransferase-like 3 (METTL3), the first identified and a critical methyltransferase, catalyzes m6A methylation on mRNA or non-coding RNA in mammals, affecting RNA metabolism. Abnormal m6A levels caused by METTL3 have been reported to be involved in different aspects of cancer development, including proliferation, apoptosis, and metastasis. In this review, we will shed light on recent findings regarding the biological function of METTL3 in gastrointestinal cancer and discuss future research directions and potential clinical applications of METTL3 for gastrointestinal cancer.
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