Blood Transfusion and Postoperative Delirium

被引：1
作者：
Whitlock E.L. [1 ]
Behrends M. [1 ]
机构：
[1] Department of Anesthesia and Perioperative Care, University of California, San Francisco, 521 Parnassus Avenue, Box 0648, San Francisco, 94143-0648, CA
来源：
Current Anesthesiology Reports | 2015年 / 5卷 / 1期
关键词：
Anemia; Delirium; Inflammation; Oxidative stress; Perioperative complications; Red blood cells; Storage lesion; Transfusion;
D O I：
10.1007/s40140-014-0085-2
中图分类号：
学科分类号：
摘要：
Postoperative delirium (POD) is a common complication of surgery associated with significant morbidity and mortality. Transfusion of packed red blood cells has been reproducibly associated with POD in many retrospective and prospective cohort studies. We review the biological evidence for a potential causal pathway between transfusion and delirium via oxidative stress and neuroinflammation, and summarize the clinical literature on delirium and transfusion to date. © 2014, Springer Science + Business Media New York.
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页码：24 / 32
页数：8
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