A promising frontier: targeting NETs for stroke treatment breakthroughs

被引：7

作者：

Fang, Huijie ^{[1
]}

Bo, Yunfei ^{[1
]}

Hao, Zhongfei ^{[1
]}

Mang, Ge ^{[2
]}

Jin, Jiaqi ^{[3
]}

Wang, Hongjun ^{[1
]}

机构：

[1] Harbin Med Univ, Affiliated Hosp 2, Dept Neurosurg, Harbin 150001, Peoples R China

[2] Harbin Med Univ, Affiliated Hosp 2, Dept Cardiol, Harbin, Peoples R China

[3] Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing 100053, Peoples R China

来源：

CELL COMMUNICATION AND SIGNALING | 2024年 / 22卷 / 01期

关键词：

Neutrophil extracellular trap; Neutrophil; Ischaemic stroke; t-PA; NEUTROPHIL EXTRACELLULAR TRAPS; TISSUE-PLASMINOGEN ACTIVATOR; ACUTE ISCHEMIC-STROKE; BLOOD-BRAIN-BARRIER; INDUCED MOVEMENT THERAPY; REGULATORY T-CELLS; PYRUVATE-KINASE; HEMORRHAGIC TRANSFORMATION; CHROMATIN DECONDENSATION; CEREBRAL-ISCHEMIA;

D O I：

10.1186/s12964-024-01563-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Stroke is a prevalent global acute cerebrovascular condition, with ischaemic stroke being the most frequently occurring type. After a stroke, neutrophils accumulate in the brain and subsequently generate and release neutrophil extracellular traps (NETs). The accumulation of NETs exacerbates the impairment of the blood-brain barrier (BBB), hampers neovascularization, induces notable neurological deficits, worsens the prognosis of stroke patients, and can facilitate the occurrence of t-PA-induced cerebral haemorrhage subsequent to ischaemic stroke. Alternative approaches to pharmacological thrombolysis or endovascular thrombectomy are being explored, and targeting NETs is a promising treatment that warrants further investigation.

引用

页数：19

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