A promising frontier: targeting NETs for stroke treatment breakthroughs

被引:4
作者
Fang, Huijie [1 ]
Bo, Yunfei [1 ]
Hao, Zhongfei [1 ]
Mang, Ge [2 ]
Jin, Jiaqi [3 ]
Wang, Hongjun [1 ]
机构
[1] Harbin Med Univ, Affiliated Hosp 2, Dept Neurosurg, Harbin 150001, Peoples R China
[2] Harbin Med Univ, Affiliated Hosp 2, Dept Cardiol, Harbin, Peoples R China
[3] Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing 100053, Peoples R China
关键词
Neutrophil extracellular trap; Neutrophil; Ischaemic stroke; t-PA; NEUTROPHIL EXTRACELLULAR TRAPS; TISSUE-PLASMINOGEN ACTIVATOR; ACUTE ISCHEMIC-STROKE; BLOOD-BRAIN-BARRIER; INDUCED MOVEMENT THERAPY; REGULATORY T-CELLS; PYRUVATE-KINASE; HEMORRHAGIC TRANSFORMATION; CHROMATIN DECONDENSATION; CEREBRAL-ISCHEMIA;
D O I
10.1186/s12964-024-01563-4
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Stroke is a prevalent global acute cerebrovascular condition, with ischaemic stroke being the most frequently occurring type. After a stroke, neutrophils accumulate in the brain and subsequently generate and release neutrophil extracellular traps (NETs). The accumulation of NETs exacerbates the impairment of the blood-brain barrier (BBB), hampers neovascularization, induces notable neurological deficits, worsens the prognosis of stroke patients, and can facilitate the occurrence of t-PA-induced cerebral haemorrhage subsequent to ischaemic stroke. Alternative approaches to pharmacological thrombolysis or endovascular thrombectomy are being explored, and targeting NETs is a promising treatment that warrants further investigation.
引用
收藏
页数:19
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