A DNA strand-nicking principle of a higher plant,caesalpinia sappan

被引：34
作者：
Mar Woongchon
Lee Hyun-Tai
Je Kang-Hoon
Choi Hye-Young
Seo Eun-Kyoung
机构：
[1] Seoul National University,Natural Products Research Institute, College of Pharmacy
[2] Ewha Womans University,Natural Products Chemistry Laboratory, College of Pharmacy
[3] Ewha Womans University,Natural Products Chemistry Laboratory, College of Pharmacy
来源：
Archives of Pharmacal Research | 2003年 / 26卷 / 2期
关键词：
DNA strand-scission; Brazilin;
D O I：
10.1007/BF02976661
中图分类号：
学科分类号：
摘要：
To find anticancer agents from higher plants, DNA strand-scission assay method was employed for bioassay-guided fractionation as well as for screening the crude extracts. During the screening, an ethyl acetate extracts of the heartwood ofCaesalpinia sappan L. (Leguminosae) exhibited potent DNA strand-scission activity. Therefore, the ethyl acetate extracts of the dried heartwood ofC. sappan was subjected to the bioassay-guided fractionation, which led to the isolation of a known compound, brazilin (1) as the active constituent. In addition, caesalpine J (2) was also isolated as an inactive constituent.
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页码：147 / 150
页数：3
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