A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer

被引:0
作者
Folefac Aminkeng
Amit P Bhavsar
Henk Visscher
Shahrad R Rassekh
Yuling Li
Jong W Lee
Liam R Brunham
Huib N Caron
Elvira C van Dalen
Leontien C Kremer
Helena J van der Pal
Ursula Amstutz
Michael J Rieder
Daniel Bernstein
Bruce C Carleton
Michael R Hayden
Colin J D Ross
机构
[1] Centre for Molecular Medicine and Therapeutics,Department of Medical Genetics
[2] University of British Columbia,Department of Pediatrics, Division of Translational Therapeutics
[3] Child and Family Research Institute,Department of Pediatrics
[4] University of British Columbia,Department of Pediatrics, Division of Pediatric Hematology/Oncology/Blood and Marrow Transplantation
[5] Amalia Children's Hospital,Department of Pediatric Oncology
[6] Radboud University Medical Center,Department of Medical Oncology
[7] University of British Columbia,Department of Pediatrics
[8] Translational Laboratory in Genetic Medicine,Division of Pediatric Cardiology
[9] National University of Singapore and Association for Science,undefined
[10] Technology and Research (A*STAR),undefined
[11] Emma Children's Hospital/Academic Medical Center,undefined
[12] Emma Children's Hospital/Academic Medical Center,undefined
[13] University of Western Ontario,undefined
[14] Stanford University,undefined
[15] Pharmaceutical Outcomes Programme,undefined
[16] British Columbia Children's Hospital,undefined
[17] Alberta Children's Hospital,undefined
[18] Calgary,undefined
[19] Stollery Children's Hospital,undefined
[20] Edmonton,undefined
[21] Winnipeg Health Sciences Centre,undefined
[22] London Health Sciences Centre,undefined
[23] McMaster Children's Hospital,undefined
[24] Hospital for Sick Children,undefined
[25] Kingston General Hospital,undefined
[26] Children's Hospital of Eastern Ontario,undefined
[27] CHU Sainte-Justine,undefined
[28] McGill University Health Centre–Montréal Children's Hospital,undefined
[29] IWK Health Centre,undefined
[30] Halifax,undefined
[31] Janeway Children's Hospital,undefined
[32] St. John's,undefined
[33] Present address: Institute of Clinical Chemistry,undefined
[34] Inselspital Bern University Hospital,undefined
[35] and University of Bern,undefined
[36] Bern,undefined
[37] Switzerland.,undefined
来源
Nature Genetics | 2015年 / 47卷
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学科分类号
摘要
Colin Ross and colleagues report the results of a genome-wide association study of anthracycline-induced cardiotoxicity in children treated for cancer. They identify a nonsynonymous coding variant in RARG associated with roughly fivefold higher risk of developing this severe adverse drug reaction.
引用
收藏
页码:1079 / 1084
页数:5
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