A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer

被引：0

作者：

Folefac Aminkeng

Amit P Bhavsar

Henk Visscher

Shahrad R Rassekh

Yuling Li

Jong W Lee

Liam R Brunham

Huib N Caron

Elvira C van Dalen

Leontien C Kremer

Helena J van der Pal

Ursula Amstutz

Michael J Rieder

Daniel Bernstein

Bruce C Carleton

Michael R Hayden

Colin J D Ross

机构：

[1] Centre for Molecular Medicine and Therapeutics,Department of Medical Genetics

[2] University of British Columbia,Department of Pediatrics, Division of Translational Therapeutics

[3] Child and Family Research Institute,Department of Pediatrics

[4] University of British Columbia,Department of Pediatrics, Division of Pediatric Hematology/Oncology/Blood and Marrow Transplantation

[5] Amalia Children's Hospital,Department of Pediatric Oncology

[6] Radboud University Medical Center,Department of Medical Oncology

[7] University of British Columbia,Department of Pediatrics

[8] Translational Laboratory in Genetic Medicine,Division of Pediatric Cardiology

[9] National University of Singapore and Association for Science,undefined

[10] Technology and Research (A*STAR),undefined

[11] Emma Children's Hospital/Academic Medical Center,undefined

[12] Emma Children's Hospital/Academic Medical Center,undefined

[13] University of Western Ontario,undefined

[14] Stanford University,undefined

[15] Pharmaceutical Outcomes Programme,undefined

[16] British Columbia Children's Hospital,undefined

[17] Alberta Children's Hospital,undefined

[18] Calgary,undefined

[19] Stollery Children's Hospital,undefined

[20] Edmonton,undefined

[21] Winnipeg Health Sciences Centre,undefined

[22] London Health Sciences Centre,undefined

[23] McMaster Children's Hospital,undefined

[24] Hospital for Sick Children,undefined

[25] Kingston General Hospital,undefined

[26] Children's Hospital of Eastern Ontario,undefined

[27] CHU Sainte-Justine,undefined

[28] McGill University Health Centre–Montréal Children's Hospital,undefined

[29] IWK Health Centre,undefined

[30] Halifax,undefined

[31] Janeway Children's Hospital,undefined

[32] St. John's,undefined

[33] Present address: Institute of Clinical Chemistry,undefined

[34] Inselspital Bern University Hospital,undefined

[35] and University of Bern,undefined

[36] Bern,undefined

[37] Switzerland.,undefined

来源：

Nature Genetics | 2015年 / 47卷

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摘要：

Colin Ross and colleagues report the results of a genome-wide association study of anthracycline-induced cardiotoxicity in children treated for cancer. They identify a nonsynonymous coding variant in RARG associated with roughly fivefold higher risk of developing this severe adverse drug reaction.

引用

页码：1079 / 1084

页数：5