Radiation enteritis.

被引:86
作者
Bismar M.M. [1 ]
Sinicrope F.A. [1 ]
机构
[1] Department of Gastrointestinal Medicine and Nutrition, M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 436, Houston, 77030, TX
关键词
Sucralfate; Amifostine; Radiation Injury; Radiation Enteritis; Home Parenteral Nutrition;
D O I
10.1007/s11894-002-0005-3
中图分类号
学科分类号
摘要
The frequent use of radiotherapy for abdominal and pelvic malignancies results in an increased risk of radiation enteritis. An increased understanding of the tissue response and the clinical features of radiation enteritis has led to advances in the prevention and management of this condition. Importantly, improvements in the delivery of radiotherapy, including techniques to reduce the amount of exposed small intestine in the radiation field, represent a critical strategy for prevention. Data indicate that radioprotectant agents have the potential to reduce intestinal mucosal injury and may be beneficial in reducing both acute and chronic side effects of radiotherapy.
引用
收藏
页码:361 / 365
页数:4
相关论文
共 125 条
[1]  
Sher ME(1990)Radiation induced enteropathy Am J Gastroenterol 85 121-128
[2]  
Bauer J(1972)Cell cycle dependence on the lethal radiation response in mammalian cells Curr Top Radiat Res Q 1 264-284
[3]  
Sinclair WK(1974)Complications of radiation therapy: the alimentary tract Semin Roentgenol 9 51-63
[4]  
Roswit B(1985)Vascular changes in radiation bowel disease Histopathology 9 517-534
[5]  
Hasleton PS(1995)Abnormal intestinal motility pattern explains enteric colonization with gram-negative bacilli in late radiation enteropathy Gastroenterology 109 1078-1089
[6]  
Carr N(1986)Radiation-induced intestinal pseudo-obstruction Gastroenterology 91 994-998
[7]  
Schofield PF(1995)Induction of apoptosis by tumor suppressor genes and oncogenes Semin Cancer Biol 6 17-25
[8]  
Husebye E(1980)Tolerance of the intestine to radiation therapy Surg Gynecol Obstet 151 273-284
[9]  
Skar V(1982)Importance of predisposing factors in the development of enteric damage Am J Clin Oncol 5 189-194
[10]  
Hoverstad T(1971)Morphological and functional response of human small intestine to ionizing radiation Scand J Gastroenterol 6 1-52