The emerging role of natriuretic peptides in the diagnosis and treatment of decompensated heart failure.

被引：8
作者：
Gallagher M.J. [1 ]
McCullough P.A. [1 ]
机构：
[1] Division of Clinical Nutrition and Preventive Medicine, William Beaumont Hospital, 4949 Coolidge Highway, Royal Oak, 48073, MI
来源：
Current Heart Failure Reports | 2004年 / 1卷 / 3期
关键词：
Natriuretic Peptide; Dobutamine; Brain Natriuretic Peptide; Pulmonary Capillary Wedge Pressure; Decompensated Heart Failure;
D O I：
10.1007/s11897-004-0022-7
中图分类号：
学科分类号：
摘要：
B-type natriuretic peptide (BNP) is a cardiac neurohormone and is released as prepro BNP and then enzymatically cleaved to the N-terminal proBNP (NT-proBNP) and BNP upon ventricular myocyte stretch. Blood measurements of BNP and NT-proBNP have been used to identify patients with heart failure (HF). Clinical considerations for these tests include their half-lives in plasma, dependence on renal function for clearance, interpretation of their units of measure, and the rapid availability of the test results. The BNP assay is currently used as a diagnostic and prognostic aid in HF. In general, a BNP level below 100 pg/mL excludes acutely decompensated HF. Recombinant, human BNP (nesiritide) is an approved intravenous treatment for acute, decompensated HF. This paper reviews the literature concerning the use of this peptide as a diagnostic test and as an intravenous therapy.
引用
收藏
页码：129 / 135
页数：6
相关论文
共 109 条
[11]  
Levin ER(2003)B-type natriuretic peptide and renal function in the diagnosis of heart failure: an analysis from the Breathing Not Properly Multinational Study Am J Kidney Dis 41 571-579
[12]  
Gardner DG(2002)Utility of B-natriuretic peptide in detecting diastolic dysfunction. Comparison with Doppler velocity recordings Circulation 105 595-601
[13]  
Samson WK(2003)Bedside B-type natriuretic peptide in the emergency diagnosis of heart failure with reduced or preserved ejection fraction J Am Coll Cardiol 41 2010-2017
[14]  
Kazanegra R(2001)Role of brain natriuretic peptide in risk stratification of patients with congestive heart failure J Am Coll Cardiol 38 1934-1941
[15]  
Cheng V(2002)B-type natriuretic peptide predicts future cardiac events in patients presenting to the emergency department with dyspnea Ann Emerg Med 39 131-138
[16]  
Garcia A(2002)B-type natriuretic peptide predicts sudden death in patients with chronic heart failure Circulation 105 2392-2397
[17]  
Maisel AS(2003)Prolonged QTc interval and high B-type natriuretic peptide levels together predict mortality in patients with advanced heart failure Circulation 107 1764-1769
[18]  
McCullough PA(2003)Cardiac troponin I is associated with impaired hemodynamics, progressive left ventricular dysfunction, and increased mortality rates in advanced heart failure Circulation 108 833-838
[19]  
McCullough PA(2002)Preliminary data on the potential usefulness of B-type natriuretic peptide levels in predicting outcome after hospital discharge in patients with heart failure Am J Med 113 215-219
[20]  
Sandberg KR(2001)A rapid bedside test for B-type peptide predicts treatment outcomes in patients admitted for decompensated heart failure: a pilot study J Am Coll Cardiol 37 386-391
12345678910