The emerging role of natriuretic peptides in the diagnosis and treatment of decompensated heart failure.

被引：8
作者：
Gallagher M.J. [1 ]
McCullough P.A. [1 ]
机构：
[1] Division of Clinical Nutrition and Preventive Medicine, William Beaumont Hospital, 4949 Coolidge Highway, Royal Oak, 48073, MI
来源：
Current Heart Failure Reports | 2004年 / 1卷 / 3期
关键词：
Natriuretic Peptide; Dobutamine; Brain Natriuretic Peptide; Pulmonary Capillary Wedge Pressure; Decompensated Heart Failure;
D O I：
10.1007/s11897-004-0022-7
中图分类号：
学科分类号：
摘要：
B-type natriuretic peptide (BNP) is a cardiac neurohormone and is released as prepro BNP and then enzymatically cleaved to the N-terminal proBNP (NT-proBNP) and BNP upon ventricular myocyte stretch. Blood measurements of BNP and NT-proBNP have been used to identify patients with heart failure (HF). Clinical considerations for these tests include their half-lives in plasma, dependence on renal function for clearance, interpretation of their units of measure, and the rapid availability of the test results. The BNP assay is currently used as a diagnostic and prognostic aid in HF. In general, a BNP level below 100 pg/mL excludes acutely decompensated HF. Recombinant, human BNP (nesiritide) is an approved intravenous treatment for acute, decompensated HF. This paper reviews the literature concerning the use of this peptide as a diagnostic test and as an intravenous therapy.
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页码：129 / 135
页数：6
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