The Effect of Temperature on Hydrogen Bonding in Crystalline and Amorphous Phases in Dihydropyrine Calcium Channel Blockers

被引：0
作者：
Xiaolin Charlie Tang
Michael J. Pikal
Lynne S. Taylor
机构：
[1] University of Connecticut,School of Pharmacy, U
[2] AstraZeneca R&D Mölndal,2092
[3] S-431 83,Solid State Analysis, Pharmaceutical and Analytical R&D
来源：
Pharmaceutical Research | 2002年 / 19卷
关键词：
crystalline; amorphous; hydrogen bonding; vibrational spectroscopy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose: To investigate the effect of temperature on hydrogen bonding in a series of structurally related amorphous and crystalline compounds to gain a better molecular-level understanding of structural differences in the various phases.
引用
收藏
页码：484 / 490
页数：6
相关论文
共 51 条
[1]  
Ediger M. D.(1996)Supercooled liquids and glasses J. Phys. Chem. 100 13200-13212
[2]  
Angell C. A.(1971)Pharmaceutical applications of solid dispersion systems J. Pharm. Sci. 60 1281-1302
[3]  
Nagel S. R.(1999)Solid dispersion of poorly water-soluble drugs: Early promises, subsequent problems, and recent breakthroughs J. Pharm. Sci. 88 1058-1066
[4]  
Chiou W. L.(1997)Rational design of stable lyophilized protein formulations: Some practical advice Pharm. Res. 14 969-975
[5]  
Riegelman S.(1997)Characteristics and significance of the amorphous state in pharmaceutical systems J. Pharm. Sci. 86 1-12
[6]  
Serajuddin A. T. M.(2002)A spectroscopic investigation of hydrogen bond patterns in crystalline and amorphous phases in dihydropyridine calcium channel blockers Pharm. Res. 19 477-483
[7]  
Carpenter J. F.(1998)A Fourier transform infrared microspectroscopy study of sugar glasses-application to anhydrobiotic higher plant cells Biochim. Biophys. Acta 1379 83-96
[8]  
Pikal M. J.(1985)Hydrogen bonding in polymers: Infrared temperature studies of an amorphous polyamide Macromolecules 18 1676-1683
[9]  
Chang B. S.(1991)Characterization of interand intramolecular hydrogen bonding in the solid state using variable-temperature IR spectroscopy Appl. Spectrosc. 45 118-120
[10]  
Randolph T. W.(1989)Glassy state of pharmaceuticals 3: Thermal properties and stability of glassy pharmaceuticals and their binary glass systems Chem. Pharm. Bull. 37 1047-1050
123456