Expression of latent and replicative-infection genes of Epstein-Barr virus in macrophage

被引：0

作者：

M. Shimakage

M. Kimura

S. Yanoma

M. Ibe

S. Yokota

G. Tsujino

T. Kozuka

T. Dezawa

S. Tamura

A. Ohshima

M. Yutsudo

A. Hakura

机构：

[1] Clinical Research Institute,

[2] Osaka National Hospital,undefined

[3] Osaka,undefined

[4] Japan,undefined

[5] Department of Pediatrics,undefined

[6] Osaka National Hospital,undefined

[7] Osaka,undefined

[8] Japan,undefined

[9] Department of Dermatology,undefined

[10] Osaka National Hospital,undefined

[11] Osaka,undefined

[12] Japan,undefined

[13] Department of Anatomy,undefined

[14] Kansai-Shinkyu College,undefined

[15] Kumatori,undefined

[16] Japan,undefined

[17] Clinical Research Institute,undefined

[18] Kanagawa Cancer Center,undefined

[19] Yokohama,undefined

[20] Japan,undefined

[21] Department of Pediatrics,undefined

[22] School of Medicine,undefined

[23] Yokohama City University,undefined

[24] Yokohama,undefined

[25] Japan,undefined

[26] Department of Pediatrics,undefined

[27] Wakayama Medical College,undefined

[28] Wakayama,undefined

[29] Japan,undefined

[30] Department of Otorhinolaryngology,undefined

[31] Wakayama Medical College,undefined

[32] Wakayama,undefined

[33] Japan,undefined

[34] Department of 1st Pathology,undefined

[35] Wakayama Medical College,undefined

[36] Wakayama,undefined

[37] Japan,undefined

[38] Department of Tumor Virology,undefined

[39] Research Institute for Microbial Diseases,undefined

[40] Osaka University,undefined

[41] Osaka,undefined

[42] Japan,undefined

来源：

Archives of Virology | 1999年 / 144卷

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摘要：

Unlike other herpesviruses, Epstein-Barr virus (EBV) has not yet been shown to infect macrophages. Six macrophage cultures were isolated from normal and affected samples. Nested polymerase chain reaction revealed the existence of the EBV genome in all these macrophages. EBV latent genes expression in all cultures were detected by mRNA in situ hybridization and immunofluorescence staining. Some cultures also expressed EBV replicative-infection proteins, while in other cultures induction of these proteins was demonstrated. These findings are the first to show expression of several latent and replicative-infection genes of EBV in macrophages, indicating that EBV proliferates in macrophages.

引用

页码：157 / 166

页数：9