Postoperative infections after oesophageal resections: The role of blood transfusions

被引：8

作者：

Rovera F. ^{[1
]}

Dionigi G. ^{[1
]}

Boni L. ^{[1
]}

Imperatori A. ^{[1
]}

Tabacchi A. ^{[1
]}

Carcano G. ^{[1
]}

Diurni M. ^{[1
]}

Dionigi R. ^{[1
]}

机构：

[1] Department of Surgical Sciences, University of Insubria, Varese

来源：

World Journal of Surgical Oncology | / 4卷 / 1期

关键词：

Blood Transfusion; Postoperative Infection; Oesophageal Cancer; Infective Complication; Anastomotic Healing;

D O I：

10.1186/1477-7819-4-80

中图分类号：

学科分类号：

摘要：

Background: Perioperative blood transfusion carries numerous potential risks concerning the transmission of infective diseases and immunodepression that can facilitate the occurrence of postoperative infectious complications. Explanation of connections between perioperative blood transfusion and postoperative septic complication worldwide is not well documented. Many studies have described a correlation between perioperative blood transfusions and postoperative infections. On the contrary, other studies indicate that factors influencing the need for blood transfusions during surgery have a greater bearing than blood transfusion per se on the occurrence of postoperative complications. Patients and methods: A prospective study was conducted in our Department on 110 consecutive patients undergoing oesophageal resection for primary cancer, in order to evaluate the incidence of postoperative infections related to perioperative allogenic blood transfusions. For each patient we preoperatively recorded in a computerized data-base several known risk-factors for postoperative infections; in detail we registered the administration of allogenic perioperative blood transfusions (period of administration, number of packages administered). Results: Among the enrolled 110 patients, 53 (48%) received perioperative blood transfusions: in this group postoperative infections (overall infective complications) occurred in 27 patients. After a multivariate analysis we observed that perioperative blood transfusions significantly affected as an independent variable the development of wound infections (p = 0.02). Conclusion: Blood transfusions independently affected the incidence of wound infections in patients who underwent oesophageal resection for primary cancer. © 2006 Rovera et al; licensee BioMed Central Ltd.

引用

共 31 条

[1]

Tsutsui S., Moriguchi S., Morita M., Multivariate anaysis of postoperative complications after esophageal resection, Ann Thorac Surg, 53, pp. 1052-1056, (1992)

[2]

Bartels H., Stein H.J., Siewert J.R., Preoperative risk analysis amnd postoperative mortality of oesophagectomy for respectable oesophageal cancer, Br J Surg, 85, pp. 840-844, (1998)

[3]

Whooley B.P., Law S., Murthy S.C., Alexandrou A., Wong J., Analysis of reduced death and complication rates after esophageal resection, Ann Surg, 233, pp. 338-344, (2001)

[4]

Altemeier W.A., Burke J.F., Pruitt Jr. B.A., Sandusky W.R., Manual on Control of Infection in Surgical Patients, (1984)

[5]

Nichols R.L., Smith J.W., Klein D.B., Trunkey D.D., Cooper R.H., Adinolfi M.F., Mills J., Risk of Infection after penetrating abdominal trauma, N Engl J Med, 311, pp. 1065-1070, (1984)

[6]

Tartter P.J., Quintero S., Barron D.M., Perioperative blood transfusion associated with infectious complications after colorectal cancer operations, Am J Surg, 152, pp. 479-482, (1986)

[7]

Edna T.H., Bjerkeset T., Association between transfusion of stored blood and infective bacterial complications after resection for colorectal cancer, Eur J Surg, 164, pp. 449-456, (1998)

[8]

Braga M., Vignali A., Radaelli G., Gianotti L., Di Carlo V., Association between perioperative blood transfusion and postoperative infection in patients having elective operations for gastrointestinal cancer, Eur J Surg, 158, pp. 531-536, (1992)

[9]

Tang R., Chen H.H., Wang Y.L., Changchien C.R., Chen J.S., Hsu K.C., Chiang J.M., Wang J.Y., Risk factors for surgical site infection after elective resection of the colon and rectum: A single-center prospective study of 2,809 consecutive patients, Ann Surg, 234, pp. 181-189, (2001)

[10]

Innerhofer P., Klingler A., Klimmer C., Fries D., Nussbaumer W., Risk for postoperative infection after transfusion of white blood cell-filtered allogeneic or autologous blood components in orthopaedic patients undergoing primary arthroplasty, Transfusion, 45, pp. 103-110, (2005)

← 1 2 3 4 →