Early growth response-1 in the pathogenesis of cardiovascular disease

被引:0
作者
Levon M. Khachigian
机构
[1] University of New South Wales,School of Medical Sciences, Faculty of Medicine
来源
Journal of Molecular Medicine | 2016年 / 94卷
关键词
Restenosis; Transcription factors; Smooth muscle cells; Egr-1;
D O I
暂无
中图分类号
学科分类号
摘要
This article reviews the regulatory roles of the immediate-early gene product and prototypic zinc finger transcription factor, early growth response-1 in models of cardiovascular pathobiology, focusing on insights using microRNA, DNAzymes, small hairpin RNA, small interfering RNA, oligonucleotide decoy strategies and mice deficient in early growth response-1.
引用
收藏
页码:747 / 753
页数:6
相关论文
共 542 条
[11]  
Lau LF(1996)Egr-1-induced endothelial gene expression: a common theme in vascular injury Science 271 1427-1431
[12]  
Nathans D(1989)DNA binding site of the growth factor-inducible protein Zif268 Proc Natl Acad Sci U S A 86 8737-8741
[13]  
Lim RW(1993)Detection and characterization of cellular EGR-1 binding to its own recognition site J Biol Chem 268 16949-16957
[14]  
Varnum BC(1988)Molecular cloning, sequencing, and mapping of EGR2, a human early growth response gene encoding a protein with “zinc-binding finger” structure Proc Natl Acad Sci U S A 85 7164-7168
[15]  
Herschman HR(1991)EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors Oncogene 6 917-928
[16]  
Milbrandt J(1992)Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C Proc Natl Acad Sci U S A 89 4739-4743
[17]  
Lemaire P(2003)Egr-1 target genes in human endothelial cells identified by microarray analysis Gene 315 33-41
[18]  
Revelant O(2013)Early growth response 3 (Egr-3) is induced by transforming growth factor-beta and regulates fibrogenic responses Am J Pathol 183 1197-1208
[19]  
Bravo R(2015)Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells Science 347 1010-1014
[20]  
Charnay P(2010)Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin-1beta induction of early growth response 1 transcription Arterioscler Thromb Vasc Biol 30 536-545