Early growth response-1 in the pathogenesis of cardiovascular disease

被引：0
作者：
Levon M. Khachigian
机构：
[1] University of New South Wales,School of Medical Sciences, Faculty of Medicine
来源：
Journal of Molecular Medicine | 2016年 / 94卷
关键词：
Restenosis; Transcription factors; Smooth muscle cells; Egr-1;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This article reviews the regulatory roles of the immediate-early gene product and prototypic zinc finger transcription factor, early growth response-1 in models of cardiovascular pathobiology, focusing on insights using microRNA, DNAzymes, small hairpin RNA, small interfering RNA, oligonucleotide decoy strategies and mice deficient in early growth response-1.
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页码：747 / 753
页数：6
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共 542 条
  • [1] Cao XM(1990)Identification and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signals Mol Cell Biol 10 1931-1939
  • [2] Koski RA(1989)Functional serum response elements upstream of the growth factor-inducible gene, zif268 Mol Cell Biol 9 4889-4895
  • [3] Gashler A(1987)Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc Proc Natl Acad Sci U S A 84 1182-1186
  • [4] McKiernan M(1987)Cloning of tetradecanoyl phorbol ester-induced ‘primary response’ sequences and their expression in density-arrested Swiss 3T3 cells and a TPA non-proliferative variant Oncogene 1 263-270
  • [5] Morris CF(1987)A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor Science 238 797-799
  • [6] Gaffney R(1988)Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells Proc Natl Acad Sci U S A 85 4691-4695
  • [7] Hay RV(1995)Early growth response protein 1 (Egr-1): prototype of a zinc-finger family of transcription factors Prog Nucl Acid Res 50 191-224
  • [8] Sukhatme VP(2000)High-level expression of Egr-1 and Egr-1-inducible genes in mouse and human atherosclerosis J Clin Invest 105 653-662
  • [9] Christy B(2013)Flow cytometry and gene expression profiling of immune cells of the carotid plaque and peripheral blood Atherosclerosis 229 338-347
  • [10] Nathans D(2015)Egr-1 identifies neointimal remodeling and relates to progression in human pulmonary arterial hypertension J Heart Lung Transplant 35 481-490
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