Integrated gene networks in breast cancer development

被引：0
作者：
Ivana Ratkaj
Emil Stajduhar
Srdan Vucinic
Sime Spaventi
Hrvojka Bosnjak
Kresimir Pavelic
Sandra Kraljevic Pavelic
机构：
[1] University of Rijeka,Department of Biotechnology
[2] Clinical hospital “Sisters of mercy”,Department of Radiology
[3] Ruder Boskovic Institute,Laboratory for Systems Biomedicine, Division of Molecular Medicine
[4] Croatian Academy of Sciences and Arts,Department of Internal Medicine
[5] Clinical hospital “Sisters of mercy”,undefined
来源：
Functional & Integrative Genomics | 2010年 / 10卷
关键词：
Breast cancer; Proteomics; Genomics; hGH; Pax5; HOXA1; Cancer profile;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Breast cancer is a complex and heterogenous disease. Classical molecular medical approaches cannot fully understand and comprehend its pathogenesis. In this review, the development of new biological markers for the early detection and creation of guided and specific therapy of breast cancer are discussed in light of the rapid advances in the “omics”. Results of cancer research in combination with large-scale methods that examine the expression status of genes and proteins have identified a large number of new biomarkers as well as confirmed the human growth hormone as an important player in the pathogenesis of this disease through its autocrine regulation where it influences the activation of Pax5 and HOXA1 gene networks.
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页码：11 / 19
页数：8
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