Predictive, preventive and personalised medicine for age-related macular degeneration

被引：5

作者：

Hasler P.W. ^{[1
]}

Flammer J. ^{[1
]}

机构：

[1] University Eye Clinic Basel, Basel

来源：

EPMA Journal | 2010年 / 1卷 / 2期

关键词：

Age-related macular degeneration; Blindness; Macula; Ophthalmology; Prevention; Retina; Treatment;

D O I：

10.1007/s13167-010-0017-2

中图分类号：

学科分类号：

摘要：

Age-related macular degeneration (AMD) is an ophthalmologic disease which usually affects older adults and represents the leading cause of legal blindness in Europe and the United States of America. The pathogenesis of AMD is complex and, nowadays, the treatments are targeting more the late form of the disease. Age and genetic make-up are the most important risk factors identified to date. There are undoubtedly environmental and other risk factors involved and the adverse effect of smoking is well established. New treatments for AMD have emerged with improved prognostic outcome. This remarkable advances in our understanding of the genetic and biological foundations of this disease were derived from a recent convergence of scientific and clinical data. In the near future we will have several therapeutic options for treatment of AMD at different stages and therefore personalising more and more the treatment. © 2010 European Association for Predictive, Preventive and Personalised Medicine.

引用

页码：245 / 251

页数：6

共 44 条

[1]

Vingerling J.R., Dielemans I., Hofman A., Grobbee D.E., Hijmering M., Kramer C.F., Et al., The prevalence of age-related maculopathy in the Rotterdam study, Ophthalmology, 102, pp. 205-210, (1995)

[2]

Vingerling J.R., Klaver C.C., Hofman A., de Jong P.T., Epidemiology of age-related maculopathy, Epidemiol Rev., 17, pp. 347-360, (1995)

[3]

Tomany S.C., Klein R., Klein B.E., The relationship between iris color, hair color, and skin sun sensitivity and the 10-year incidence of age-related maculopathy: the Beaver Dam Eye Study, Ophthalmology, 110, pp. 1526-1533, (2003)

[4]

Bockelbrink A., Roll S., Ruether K., Rasch A., Greiner W., Willich S.N., Cataract surgery and the development or progression of age-related macular degeneration: a systematic review, Surv Ophthalmol, 53, pp. 359-367, (2008)

[5]

Holz F.G., Sheraidah G., Pauleikhoff D., Bird A.C., Analysis of lipid deposits extracted from human macular and peripheral Bruch's membrane, Arch Ophthalmol, 112, pp. 402-406, (1994)

[6]

Klein R., Klein B.E., Moss S.E., Diabetes, hyperglycemia, and age-related maculopathy. The beaver dam eye study, Ophthalmology, 99, pp. 1527-1534, (1992)

[7]

Young R.W., Solar radiation and age-related macular degeneration, Surv Ophthalmol., 32, pp. 252-269, (1988)

[8]

Smith W., Assink J., Klein R., Mitchell P., Klaver C.C., Klein B.E., Et al., Risk factors for age-related macular degeneration: pooled findings from three continents, Ophthalmology, 108, pp. 697-704, (2001)

[9]

Evans J.R., Fletcher A.E., Wormald R.P., 28, 000 Cases of age related macular degeneration causing visual loss in people aged 75 years and above in the United Kingdom may be attributable to smoking, Br J Ophthalmol., 89, pp. 550-553, (2005)

[10]

Khan J.C., Thurlby D.A., Shahid H., Clayton D.G., Yates J.R., Bradley M., Et al., Smoking and age related macular degeneration: the number of pack years of cigarette smoking is a major determinant of risk for both geographic atrophy and choroidal neovascularisation, Br J Ophthalmol., 90, pp. 75-80, (2006)

← 1 2 3 4 5 →