In Vitro Characterization and in Vivo Testosterone Suppression of 6-Month Release Poly(D,L-Lactide) Leuprolide Microspheres

被引:0
作者
Byung Ho Woo
Kyu-Heum Na
Bhas A. Dani
Ge Jiang
B. C. Thanoo
Patrick P. DeLuca
机构
[1] University of Kentucky,Faculty of Pharmaceutical Sciences, College of Pharmacy
[2] Oakwood Laboratories,undefined
来源
Pharmaceutical Research | 2002年 / 19卷
关键词
leuprolide; LHRH analogue; poly(D,L-lactide); microspheres; peptide stability; testosterone suppression;
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中图分类号
学科分类号
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页码:546 / 550
页数:4
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[1]  
Sato T.(1988)Porous biodegradable microspheres for controlled drug delivery. I. Assessment of processing conditions and solvent removal techniques Pharm. Res. 5 21-30
[2]  
Kanke M.(1990)In vivo assessment of salmon calcitonin sustained release from biodegradable microspheres J. Control. Release 17 199-206
[3]  
Schroeder H. G.(1995)Characterization of biodegradable poly(D,L-lactide-co-glycolide) polymers and microspheres J. Pharm. Biomed. Anal. 13 747-760
[4]  
DeLuca P. P.(1997)Effect of processing parameters on the properties of peptide-containing PLGA J. Microencapsul. 14 163-174
[5]  
Lee K. C.(1998)In vitro cellular responses to bioerodible particles loaded with recombinant human bone morphogenetic protein-2 J. Biomed. Mater. Res. 41 104-110
[6]  
Soltis E. E.(1999)Preparation and characterization of poly (D,L-lactide-coglycolide) microspheres for controlled release of poly(L-lysine) complexed plasmid DNA Pharm. Res. 16 509-513
[7]  
Newman P. S.(1999)Influence of formulation parameters on the characteristics of poly(D, L-lactide-co-glycolide) microspheres containing poly(L-lysine) complexed plasmid J. Control. Release 60 279-286
[8]  
Burton K. W.(2000)Formulation and in vitro transfection efficiency of poly(D, L-lactide-co-glycolide) microspheres containing plasmid DNA for gene delivery AAPS PharmSciTech. 1 28-315
[9]  
Mehta R. C.(2001)Preparation, characterization and in vivo evaluation of 120-day poly(D,L-lactide) leuprolide microspheres J. Control. Release 75 307-729
[10]  
DeLuca P. P.(2000)Extended release peptide delivery systems through the use of PLGA microsphere combinations J. Biomater. Sci. Polym. Ed. 11 715-296