Ligands stimulating antitumour immunity as the next G-quadruplex challenge

被引：0
作者：
Giulia Miglietta
Jessica Marinello
Marco Russo
Giovanni Capranico
机构：
[1] Alma Mater Studiorum University of Bologna,Department of Pharmacy and Biotechnology
来源：
Molecular Cancer | / 21卷
关键词：
G-quadruplex; G4 ligands; G-loop; Genome instability; Innate immunity; Cancer immunotherapy;
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摘要：
G-quadruplex (G4) binders have been investigated to discover new anticancer drugs worldwide in past decades. As these ligands are generally not highly cytotoxic, the discovery rational was mainly based on increasing the cell-killing potency. Nevertheless, no G4 binder has been shown yet to be effective in cancer patients. Here, G4 binder activity at low dosages will be discussed as a critical feature to discover ligands with therapeutic effects in cancer patients. Specific effects of G4 binders al low doses have been reported to occur in cancer and normal cells. Among them, genome instability and the stimulation of cytoplasmic processes related to autophagy and innate immune response open to the use of G4 binders as immune-stimulating agents. Thus, we propose a new rational of drug discovery, which is not based on cytotoxic potency but rather on immune gene activation at non-cytotoxic dosage.
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