CNS axonal degeneration and transport deficits at the optic nerve head precede structural and functional loss of retinal ganglion cells in a mouse model of glaucoma

被引:0
|
作者
Prabhavathi Maddineni
Ramesh B. Kasetti
Pinkal D. Patel
J. Cameron Millar
Charles Kiehlbauch
Abbot F. Clark
Gulab S. Zode
机构
[1] Department of Pharmacology and Neuroscience and the North Texas Eye Research Institute,
[2] IREB-535,undefined
[3] University of North Texas Health Science Center,undefined
来源
Molecular Neurodegeneration | / 15卷
关键词
Neurodegeneration; Ocular hypertension; Mouse model of glaucoma; Glucocorticoid-induced glaucoma; POAG; Retinal ganglion cell loss; Optic nerve degeneration; Trabecular meshwork; Intraocular pressure; Anterograde transport deficits; And optic nerve head axonal degeneration;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [41] Partial Optic Nerve Transection in Rats: A Model Established with a New Operative Approach to Assess Secondary Degeneration of Retinal Ganglion Cells
    Yan, Fancheng
    Guo, Sailiang
    Chai, Yijie
    Zhang, Lan
    Liu, Kegao
    Lu, Qingjun
    Wang, Ningli
    Li, Shuning
    JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2017, (128):
  • [42] Apolipoprotein (APOE) allelic expression, advanced age, and diet contribute to atrophic degenerative changes in retinal ganglion cells and optic nerve in a mouse model: Predictors of severity of glaucoma?
    Walsh, MM
    Malek, G
    Saloupis, P
    Sullivan, PM
    Mace, B
    Schmechel, DE
    Rickman, CB
    Rickman, DW
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2005, 46
  • [43] Baseline structural characteristics of the optic nerve head and retinal nerve fiber layer are associated with progressive visual field loss in patients with open-angle glaucoma
    Siesky, Brent
    Wentz, Scott M.
    Januleviciene, Ingrida
    Kim, Daniel H.
    Burgett, Kendall M.
    Vercellin, Alice C. Verticchio
    Rowe, Lucas W.
    Eckert, George J.
    Harris, Alon
    PLOS ONE, 2020, 15 (08):
  • [44] OFF transient alpha retinal ganglion cells exhibit physiological but not morphological deficits in the DBA/2J mouse model of glaucoma
    Hellmer, Chase
    Morgan, Kennedi
    White, Caitlin
    McCall, Maureen
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2023, 64 (08)
  • [45] Systemic Mesenchymal Stem Cell Treatment Mitigates Structural and Functional Retinal Ganglion Cell Degeneration in a Mouse Model of Multiple Sclerosis
    Gramlich, Oliver W.
    Brown, Alexander J.
    Godwin, Cheyanne R.
    Chimenti, Michael S.
    Boland, Lauren K.
    Ankrum, James A.
    Kardon, Randy H.
    TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, 2020, 9 (08):
  • [46] In vivo effects of single or combined topical neuroprotective and regenerative agents on degeneration of retinal ganglion cells in rat optic nerve crush model
    Kitamura, Yuta
    Bikbova, Guzel
    Baba, Takayuki
    Yamamoto, Shuichi
    Oshitari, Toshiyuki
    SCIENTIFIC REPORTS, 2019, 9 (1)
  • [47] In vivo effects of single or combined topical neuroprotective and regenerative agents on degeneration of retinal ganglion cells in rat optic nerve crush model
    Yuta Kitamura
    Guzel Bikbova
    Takayuki Baba
    Shuichi Yamamoto
    Toshiyuki Oshitari
    Scientific Reports, 9
  • [48] Effects of lighting environment on the degeneration of retinal ganglion cells in glutamate/aspartate transporter deficient mice, a mouse model of normal tension glaucoma
    Ohashi, Tsutomu
    Namekata, Kazuhiko
    Guo, Xiaoli
    Kimura, Atsuko
    Harada, Chikako
    Harada, Takayuki
    BIOCHEMISTRY AND BIOPHYSICS REPORTS, 2022, 29
  • [49] Compromised Blood Flow in the Optic Nerve Head after Systemic Administration of Aldosterone in Rats: A Possible Rat Model of Retinal Ganglion Cell Loss
    Wada, Yasushi
    Higashide, Tomomi
    Sakaguchi, Kimikazu
    Nagata, Atsushi
    Hirooka, Kazuyuki
    Sugiyama, Kazuhisa
    CURRENT EYE RESEARCH, 2022, 47 (05) : 777 - 785
  • [50] Loss of monocyte chemoattractant protein-1 reduced monocyte recruitment and preserved retinal ganglion cells in a mouse model of hypertensive glaucoma
    Guo, Michelle
    Schwartz, Turner D.
    Lawrence, Emily C. N.
    Lu, Jingwen
    Zhong, Anny
    Wu, Jie
    Sterling, Jacob K.
    Nikonov, Sergei
    Dunaief, Joshua L.
    Cui, Qi N.
    EXPERIMENTAL EYE RESEARCH, 2025, 254