Combined hepatocellular–cholangiocarcinoma producing parathyroid hormone-related protein: report of a case

被引:0
作者
Michinori Matsumoto
Shigeki Wakiyama
Hiroaki Shiba
Takeshi Gocho
Takeyuki Misawa
Yuichi Ishida
Mariko Itsubo
Masafumi Suzuki
Katsuhiko Yanaga
机构
[1] The Jikei University School of Medicine,Department of Surgery
[2] The Jikei University School of Medicine,Department of Internal Medicine
[3] The Jikei University School of Medicine,Department of Pathology
来源
Surgery Today | 2014年 / 44卷
关键词
Combined hepatocellular–cholangiocarcinoma; Parathyroid hormone-related protein; Hypercalcemia; Paraneoplastic syndrome;
D O I
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中图分类号
学科分类号
摘要
Combined hepatocellular–cholangiocarcinoma (CHCC) is an uncommon form of primary liver cancer. A 57-year-old man was readmitted to our hospital for treatment of recurrent CHCC, 12 months after central bisegmentectomy and 4 months after limited hepatic resection. Magnetic resonance imaging (MRI) revealed multiple hepatic nodules. Laboratory data showed increased serum levels of α-fetoprotein (AFP), calcium, and parathyroid hormone-related protein (PTH-rP), to 5,571 ng/mL, 17.0 mg/dL, and 16.1 pmol/L, respectively. Palliative mass reduction surgery was indicated by the fact that the hypercalcemia was difficult to manage medically. Thus, we performed lateral segmentectomy with partial resection of segment 7 and the caudate lobe, and microwave coagulation therapy for multiple recurrent CHCC. Thereafter, the serum PTH-rP and AFP levels decreased remarkably and the hypercalcemia was controlled for the next 3 months. He died of disease progression 9 months after the last hepatic surgery. To our knowledge, this is only the second reported case of CHCC producing PTH-rP in the English-language literature.
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页码:1577 / 1583
页数:6
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