Impact of Carboxymethylcellulose on Morphology and Antibiotic Production by Streptomyces hygroscopicus

被引：0
|
作者：
Slavica B. Ilić
Sandra S. Konstantinović
Vlada B. Veljković
Dragiša S. Savić
Miodrag L. Lazić
Gordana Gojgić-Cvijović
机构：
[1] Faculty of Technology,
[2] Institute of Chemistry,undefined
[3] Technology and Metalurgy,undefined
来源：
Current Microbiology | 2008年 / 57卷
关键词：
Fermentation; Extracellular Polymeric Substance; Fermentation Broth; Antibiotic Production; Submerged Fermentation;
D O I：
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学科分类号：
摘要：
A chemically defined media consisting of carboxymethylcellulose (CMC) was developed to maximize the production of antibiotics, hexaene H-85 and azalomycine, by Streptomyces hygroscopicus CH-7. The production of antibiotics by filamentous organisms is often dependent on the morphology and size distribution of the pellet population within the culture. By adding the polymer to the fermentation medium, the growth was changed from a single large glob to small reproducible pellets, and wall growth was diminished to a minimum. Maximum concentrations of hexaene H-85 (146.7 mg/dm3) and azalomycine (188.6 mg/dm3) were reached at 3.0% and 1.0% (w/v) CMC, respectively.
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页码：8 / 11
页数：3
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