Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease

被引：0

作者：

Xuebin Liu

Stewart Leung

Chunxia Wang

Zhu Tan

Ji Wang

Taylor B Guo

Lei Fang

Yonggang Zhao

Bing Wan

Xia Qin

Limin Lu

Runsheng Li

Heng Pan

Mingjuan Song

Ailian Liu

Jian Hong

Hongtao Lu

Jingwu Z Zhang

机构：

[1] GlaxoSmithKline Research and Development Center,Department of Neuroimmunology

[2] Baylor College of Medicine,Department of Neurology

来源：

Nature Medicine | 2010年 / 16卷

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D O I：

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学科分类号：

摘要：

Variation in the IL-7 receptor is associated with susceptibility to multiple sclerosis. Jingwu Zhang and his colleagues provide an explanation. They show that the cytokine IL-7 regulates the surival and proliferation of T helper type 17 cells—a cell type known to be involved in the pathogenesis of multiple sclerosis. The findings suggest that IL-7 antagonism could be useful in individuals with autoimmune diseases such as multiple sclerosis (pages 166–168).

引用

页码：191 / 197

页数：6

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