The lipid network

被引：7
作者：
Marc-Antoine Sani
Frances Separovic
John D. Gehman
机构：
[1] School of Chemistry, Bio21 Institute, University of Melbourne, Melbourne, VIC
来源：
Biophysical Reviews | 2012年 / 4卷 / 4期
基金：
澳大利亚研究理事会;
关键词：
Lipid composition; Lipid targeting; Lipid transformation; Membrane active peptides; Model membrane;
D O I：
10.1007/s12551-012-0071-1
中图分类号：
学科分类号：
摘要：
Natural cell membranes are composed of a remarkable variety of lipids, which provide specific biophysical properties to support membrane protein function. An improved understanding of this complexity of membrane composition may also allow the design of membrane active drugs. Crafting a relevant model of a cell membrane with controlled composition is becoming an art, with the ability to reveal the molecular mechanisms of biological processes and lead to better treatment of pathologies. By matching physiological observations from in vivo experiments to high-resolution information, more easily obtained from in vitro studies, complex interactions at the lipid interface are determined. The role of the lipid network in biological membranes is, therefore, the subject of increasing attention. © 2012 International Union for Pure and Applied Biophysics (IUPAB) and Springer.
引用
收藏
页码：283 / 290
页数：7
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