IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells

被引：0
|
作者：
Thomas Korn
Estelle Bettelli
Wenda Gao
Amit Awasthi
Anneli Jäger
Terry B. Strom
Mohamed Oukka
Vijay K. Kuchroo
机构：
[1] Center for Neurologic Diseases,
[2] Brigham and Women’s Hospital,undefined
[3] Harvard Medical School,undefined
[4] Boston,undefined
[5] Massachusetts 02115,undefined
[6] USA,undefined
[7] Transplant Research Center,undefined
[8] Beth Israel Deaconess Medical Center,undefined
[9] Harvard Medical School,undefined
[10] Boston,undefined
[11] Massachusetts 02115,undefined
[12] USA,undefined
[13] Center for Neurologic Diseases,undefined
[14] Brigham and Women’s Hospital,undefined
[15] Harvard Medical School,undefined
[16] 65 Landsdowne Street,undefined
[17] Cambridge,undefined
[18] Massachusetts 02139,undefined
[19] USA,undefined
来源：
Nature | 2007年 / 448卷
关键词：
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学科分类号：
摘要：
TH17 cells are a recently defined subset of pro-inflammatory helper T cells that are induced by the cytokines IL-6 and transforming growth factor (TGF)-β. TH17 can also be induced by an alternative pathway in which TGF-β cooperates with IL-21.
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页码：484 / 487
页数：3
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