The emerging role of RNA N6-methyladenosine methylation in breast cancer

被引：0
|
作者：
Fangchao Zheng
Feng Du
Jiuda Zhao
Xue Wang
Yiran Si
Peng Jin
Haili Qian
Binghe Xu
Peng Yuan
机构：
[1] Chinese Academy of Medical Sciences and Peking Union Medical College,Department of Medical Oncology, National Cancer Centre/National Clinical Research Center for Cancer/Cancer Hospital
[2] Peking University Cancer Hospital and Institute,Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), The VIPII Gastrointestinal Cancer Division of Medical Department
[3] Affiliated Hospital of Qinghai University & Affiliated Cancer Hospital of Qinghai University,Breast Disease Diagnosis and Treatment Center
[4] Chinese Academy of Medical Sciences and Peking Union Medical College,Department of VIP Medical Services, National Cancer Centre/National Clinical Research Center for Cancer/Cancer Hospital
[5] Chinese Academy of Medical Sciences and Peking Union Medical College,Department of Surgery, National Cancer Centre/National Clinical Research Center for Cancer/Cancer Hospital
[6] Chinese Academy of Medical Sciences and Peking Union Medical College,State Key Laboratory of Molecular Oncology, Cancer Hospital/Institute
来源：
Biomarker Research | / 9卷
关键词：
RNA methylation; Breast cancer; Clinicopathological features; Prognosis; Drug target;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
N6-methyladenosine (m6A) modification is the most prevalent internal mRNA modification and is involved in many biological processes in eukaryotes. Accumulating evidence has demonstrated that m6A may play either a promoting or suppressing role in breast cancer, including in tumorigenesis, metastasis and angiogenesis. In this review, we summarize the latest research progress on the biological function and prognostic value of m6A modification in breast cancer, as well as potential related therapeutic strategies.
引用
收藏
相关论文
共 50 条
  • [41] circRNA N6-methyladenosine methylation in preeclampsia and the potential role of N6-methyladenosine-modified circPAPPA2 in trophoblast invasion
    Zhang, Yonggang
    Yang, Hongling
    Long, Yan
    Zhang, Yipeng
    Chen, Ronggui
    Shi, Junzhu
    Chen, Jiying
    SCIENTIFIC REPORTS, 2021, 11 (01)
  • [42] Understanding the roles of N6-methyladenosine writers, readers and erasers in breast cancer
    Fang, Runping
    Ye, Lihong
    Shi, Hui
    NEOPLASIA, 2021, 23 (06): : 551 - 560
  • [43] The role of N6-methyladenosine modification in tumor angiogenesis
    Qin, Lifei
    Zeng, Xinya
    Qiu, Xinze
    Chen, Xingmei
    Liu, Shiquan
    FRONTIERS IN ONCOLOGY, 2024, 14
  • [44] Role of RNA N6-Methyladenosine Modification in Male Infertility and Genital System Tumors
    Liu, Shuai
    Lao, Yongfeng
    Wang, Yanan
    Li, Rongxin
    Fang, Xuefeng
    Wang, Yunchang
    Gao, Xiaolong
    Dong, Zhilong
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 9
  • [45] The N6-methyladenosine RNA landscape in the aged mouse hippocampus
    Huang, He
    Song, Renhua
    Wong, Justin J. -L.
    Anggono, Victor
    Widagdo, Jocelyn
    AGING CELL, 2023, 22 (01)
  • [46] The regulatory role of N6-methyladenosine RNA modification in gastric cancer: Molecular mechanisms and potential therapeutic targets
    Li, Gaofeng
    Fu, Qiru
    Liu, Cong
    Peng, Yuxi
    Gong, Jun
    Li, Shilan
    Huang, Yan
    Zhang, Haiyuan
    FRONTIERS IN ONCOLOGY, 2022, 12
  • [47] The Role of N6-Methyladenosine Modification in Microvascular Dysfunction
    Zhang, Ye-Ran
    Ji, Jiang-Dong
    Wang, Jia-Nan
    Wang, Ying
    Zhu, Hong-Jing
    Sun, Ru-Xu
    Liu, Qing-Huai
    Chen, Xue
    CELLS, 2022, 11 (20)
  • [48] Steering pluripotency and differentiation with N6-methyladenosine RNA modification
    Malla, Sandhya
    Melguizo-Sanchis, Dario
    Aguilo, Francesca
    BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 2019, 1862 (03): : 394 - 402
  • [49] MicroRNA Biogenesis Modulates mRNA N6-methyladenosine Methylation in Arabidopsis
    Yang, Zhengmei
    Hu, Jianzhong
    Li, Yuxia
    Xu, Tao
    Kang, Hunseung
    JOURNAL OF PLANT BIOLOGY, 2025, 68 (01) : 13 - 25
  • [50] Emerging Roles of N6-Methyladenosine (m6A) Epitranscriptomics in Toxicology
    Malovic, Emir
    Ealy, Alyssa
    Kanthasamy, Arthi
    Kanthasamy, Anumantha G.
    TOXICOLOGICAL SCIENCES, 2021, 181 (01) : 13 - 22
12345