Fluorinated Modification of Neo-Tanshinlactone and Antiproliferative Activity Evaluation

被引：0
作者：
Zengxin Qin
Mengfei Zhao
Kaixin Zhang
Masuo Goto
Kuo-Hsiung Lee
Jizhen Li
机构：
[1] Jilin University,Department of Organic Chemistry, College of Chemistry
[2] University of North Carolina,Natural Products Research Laboratories, UNC Eshelman School of Pharmacy
来源：
Chemistry of Natural Compounds | 2022年 / 58卷
关键词：
neo-tanshinlactone; fluorination; antiproliferative activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Several neo-tanshinlactone derivatives with fluorine or the trifluoromethyl group were synthesized and their antiproliferative activities were evaluated. Compared with neo-tanshinlactone, fluorinated derivatives showed a broad activity spectrum against human tumor lines. For a neo-tanshinlactone chemical skeleton, these results also indicated that the hydrophobic group (methyl) at C-4 position and the carbon–carbon double bond of ring-D might play a crucial role in selective antibreast cancer activity. In addition, the synthesized compounds 10 and 17 showed a broad range of antiproliferative activity with IC50 values of 15–40 μM.
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页码：398 / 403
页数：5
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