Transcriptional activation of cytochrome P450 1A1 with α-tocopherol

被引：0
|
作者：
Yu. A. Sidorova
A. Yu. Grishanova
V. V. Lyakhovich
机构：
[1] Siberian Division of the Russian Academy of Medical Sciences,Laboratory for Biochemistry of Foreign Compounds, Institute of Molecular Biology and Biophysics
来源：
Bulletin of Experimental Biology and Medicine | 2004年 / 138卷
关键词：
α-tocopherol; CYP1A1; CYP1A2; AhR; Arnt;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Peroral administration of α-tocopherol in a daily dose of 150 mg/kg for 1, 4, 8, and 12 days leads to induction of cytochromes P450 1A in male rats. Activity of CYP1A1 and CYP1A2 increased most significantly one day after α-tocopherol administration (by 2.6 and 2.7 times, respectively). CYP1A1 was immunohistochemically detected in rat liver microsomes during this period. The content of CYP1A1 mRNA significantly increased in the liver. The amount of CYP1A2 mRNA and regulatory proteins for signal activation of CYP1A1 (AhR and Arnt) remained unchanged after treatment with α-tocopherol.
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页码：233 / 236
页数：3
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