TFF3 and survivin expressions associate with a lower survival rate in gastric cancer

被引：0
作者：
Jia-Rong Meng
Hui-Zhong Tang
Kai-Zong Zhou
Wu-Hong Shen
He-Yi Guo
机构：
[1] The NO. 175 Hospital of P.L.A.,Department of Pathology
[2] Zhangzhou Health Vocation College,Department of Pathology
[3] Zhangzhou Hospital,undefined
来源：
Clinical and Experimental Medicine | 2013年 / 13卷
关键词：
Gastric cancer; Immunohistochemical staining; TFF3; Survivin; Prognosis; Survival analysis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Trefoil factor 3 (TFF3) and survivin with functions of inhibiting apoptosis are involved in the gastric cancer by overexpression. The purpose of this study is to examine the expression of TFF3 and survivin in patients’ tissue samples with gastric cancer and analyze the relationship between the protein expression and the different clinical records. By studying the expressions of TFF3 and survivin in gastric cancer through immunohistochemical staining and examining the survival rate via Kaplan–Meier analysis for gastric cancer patients, we found that the TFF3 and survivin positive expressions have a significant relationship with the lower survival rate comparing to that of negative expressions in the analyzed patients (P < 0.05). And moreover, patients with double positive TFF3 and survivin expressions have the lowest survival rate. TFF3 or survivin positive expression correlates with the lymph node metastasis, metastasis, and TNM stages of gastric cancer. Survival analysis indicates that survival rate has a close relationship with the age, tumor histology, tumor differentiation, degree of infiltration, lymph node metastasis, distant metastasis, and TNM stages (P < 0.01). Our data suggest that TFF3 and survivin expressions play a vital role in gastric cancer development, and these two proteins are important markers for prognosis in gastric cancer. Patients with gastric cancer can increase the survival rate through an earlier diagnosis and appropriate treatment.
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页码：297 / 303
页数：6
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共 156 条
[1]  
Muskett FW(2003)Solution structure of the disulfide-linked dimer of human intestinal trefoil factor (TFF3): the intermolecular orientation and interactions are markedly different from those of other dimeric trefoil proteins Biochemistry-Us 42 15139-15147
[2]  
May FE(2003)Trefoil factors and human gastric cancer (review) Int J Mol Med 12 3-9
[3]  
Westley BR(1997)Phosphorylation of γ-catenin and epidermal growth-factor receptor by intestinal trefoil factor Lab Investig 77 557-563
[4]  
Feeney J(1998)Intestinal trefoil factor controls the expression of the adenomatous polyposis coli-catenin and the E-cadherin-catenin complexes in human colon carcinoma cells Proc Natl Acad Sci 95 3122-3127
[5]  
Katoh M(2001)Induction of scattering and cellular invasion by trefoil peptides in src- and RhoA-transformed kidney and colonic epithelial cells FASEB J 15 351-361
[6]  
Liu D(2000)Intestinal trefoil factor confers colonic epithelial resistance to apoptosis Proc Natl Acad Sci 97 799-804
[7]  
Chinery R(2000)Transcription factor NF-kB signals antianoikic function of trefoil factor 3 on intestinal epithelial cells Biochem Biophys Res Commun 274 576-582
[8]  
Wilding J(2002)Expression of trefoil peptides (TFF1, TFF2, and TFF3) in gastric carcinomas, intestinal metaplasia, and non-neoplastic gastric tissues J Pathol 197 582-588
[9]  
Gullick WJ(2002)Intestinal trefoil factor: a marker of poor prognosis in gastric carcinoma Clin Cancer Res 8 1092-1099
[10]  
Kmiot W(2012)TFF3 is a normal breast epithelial protein and is associated with differentiated phenotype in early breast cancer but predisposes to invasion and metastasis in advanced disease Am J Pathol 180 904-916
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