Quorum sensing inhibitory drugs as next generation antimicrobials: Worth the effort?

被引：56
作者：
Bjarnsholt T. [1 ]
Givskov M. [1 ]
机构：
[1] BioScience and Technology, BioCentrum, Technical University of Denmark
来源：
Current Infectious Disease Reports | 2008年 / 10卷 / 1期
关键词：
Pseudomonas Aeruginosa; Azithromycin; Patulin; Quorum Sense System; Rhamnolipid Production;
D O I：
10.1007/s11908-008-0006-y
中图分类号：
学科分类号：
摘要：
Bacterial resistance poses a major challenge to the development of new antimicrobial agents. Conventional antibiotics have an inherent obsolescence because they select for development of resistant. Bacterial infections have again become a serious threat in developed countries. Particularly, elderly, immunocompromised, and hospitalized patients are susceptible to infections caused by bacteria such as Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis. These bacteria form chronic, biofilm-based infections, which are challenging because bacterial cells living as biofilm are more tolerant to antibiotics than their planktonic counterparts. Therefore, research should identify new antimicrobial agents and their corresponding targets to decrease the biofilm-forming capability or persistence of the infectious bacteria. Here, we review one such drug target: bacteria cell-to-cell communication systems, or quorom sensing. Copyright © 2008 by Current Medicine Group LLC.
引用
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页码：22 / 28
页数：6
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