Role of melatonin in the treatment of COVID-19; as an adjuvant through cluster differentiation 147 (CD147)

被引：0
作者：
Ahmet Ozer Sehirli
Serkan Sayiner
Nedime Serakinci
机构：
[1] Near East University,Department of Pharmacology, Faculty of Dentistry
[2] Near East University,Department of Biochemistry, Faculty of Veterinary Medicine
[3] Near East University,Department of Medical Genetics, Faculty of Medicine
[4] Near East University,Department of Molecular Biology and Genetics, Faculty of Arts and Sciences
来源：
Molecular Biology Reports | 2020年 / 47卷
关键词：
SARS-CoV-2; COVID-19; CD147; Melatonin; Immunomodulator;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
COVID-19 caused by the SARS-CoV-2 outbreak quickly has turned into a pandemic. However, no specific antiviral agent is yet available. In this communication, we aimed to evaluate the significance of CD147 protein and the potential protective effect of melatonin that is mediated by this protein in COVID-19. CD147 is a glycoprotein that is responsible for the cytokine storm in the lungs through the mediation of viral invasion. Melatonin use previously was shown to reduce cardiac damage by blocking the CD147 activity. Hence, melatonin, a safe drug, may prevent severe symptoms, reduce symptom severity and the adverse effects of the other antiviral drugs in COVID-19 patients. In conclusion, the use of melatonin, which is reduced in the elderly and immune-compromised patients, should be considered as an adjuvant through its CD147 suppressor and immunomodulatory effect.
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页码：8229 / 8233
页数：4
相关论文
共 193 条
[1]  
Malik YS(2020)Emerging novel coronavirus (2019-nCoV)-current scenario, evolutionary perspective based on genome analysis and recent developments Vet Q 40 68-76
[2]  
Sircar S(2020)SARS-CoV-2 invades host cells via a novel route: CD147-spike protein bioRxiv 395 497-506
[3]  
Bhat S(2020)Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Lancet 323 1843-1844
[4]  
Wang K(2020)Detection of SARS-CoV-2 in different types of clinical specimens JAMA 300 1394-1399
[5]  
Chen W(2003)Characterization of a novel coronavirus associated with severe acute respiratory syndrome Science 96 29-57
[6]  
Zhou Y-S(2016)Coronavirus spike protein and tropism changes Adv Virus Res 87 E1-E9
[7]  
Huang C(2000)A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1–9 Circ Res 532 107-110
[8]  
Wang Y(2002)Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme FEBS Lett 203 631-637
[9]  
Li X(2004)Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis J Pathol 79 14614-14621
[10]  
Wang W(2005)ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia J Virol 89 2741-2745
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