Mesenchymal stem cell mechanobiology

被引：87

作者：

Castillo A.B. ^{[1
]}

Jacobs C.R. ^{[2
]}

机构：

[1] Bone and Joint Rehabilitation Research and Development Center, VA Palo Alto Health Care System, Mail Stop: 153, Palo Alto, CA 94304

[2] Biomedical Engineering, Columbia University, 351 Engineering Terrace, New York, NY 10027

来源：

Current Osteoporosis Reports | 2010年 / 8卷 / 2期

关键词：

Mechanotransduction; Mesenchymal stem cell; Osteogenic differentiation; Tissue regeneration;

D O I：

10.1007/s11914-010-0015-2

中图分类号：

学科分类号：

摘要：

Bone marrow-derived multipotent stem and stromal cells (MSCs) are likely candidates for cell-based therapies for various conditions including skeletal disease. Advancement of these therapies will rely on an ability to identify, isolate, manipulate, and deliver stem cells in a safe and effective manner. Although it is clear that physical signals affect tissue morphogenesis, stem cell differentiation, and healing processes, integration of mechanically induced signaling events remain obscure. Mechanisms underlying sensation and interpretation of mechanical signals by stem cells are the focus of intense study. External mechanical signals have the ability to activate osteogenic signaling pathways in MSCs including Wnt, Ror2, and Runx2. It is also clear that intracellular tensile forces resulting from cell-extracellular matrix interactions play a critical role in MSC regulation. Further work is required to determine the precise role that mechanical forces play in stem cell function. © Springer Science+Business Media, LLC 2010.

引用

页码：98 / 104

页数：6

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[41]

Kearney E.M., Prendergast P.J., Campbell V.A., Mechanisms of strain-mediated mesenchymal stem cell apoptosis, J Biomech Eng, 130, (2008)

[42]

Li Y.J., Batra N.N., You L., Et al., Oscillatory fluid flow affects human marrow stromal cell proliferation and differentiation, J Orthop Res, 22, pp. 1283-1289, (2004)

[43]

Riddle R.C., Taylor A.F., Genetos D.C., Donahue H.J., MAP kinase and calcium signaling mediate fluid flow-induced human mesenchymal stem cell proliferation, Am J Physiol, 290, (2006)

[44]

Ghazanfari S., Tafazzoli-Shadpour M., Shokrgozar M.A., Effects of cyclic stretch on proliferation of mesenchymal stem cells and their differentiation to smooth muscle cells, Biochem Biophys Res Comm, 388, pp. 601-605, (2009)

[45]

Holtorf H.L., Jansen J.A., Mikos A.G., Flow perfusion culture induces the osteoblastic differentiation of marrow stroma cellscaffold constructs in the absence of dexamethasone, J Biomed Mater Res A, 72, pp. 326-334, (2005)

[46]

Datta N., Pham Q.P., Sharma U., Et al., In vitro generated extracellular matrix and fluid shear stress synergistically enhance 3D osteoblastic differentiation, Proc Natl Acad Sci U S A, 103, pp. 2488-2493, (2006)

[47]

Bjerre L., Bunger C.E., Kassem M., Mygind T., Flow perfusion culture of human mesenchymal stem cells on silicate-substituted tricalcium phosphate scaffolds, Biomaterials, 29, pp. 2616-2627, (2008)

[48]

Sandino C., Planell J.A., Lacroix D., A finite element study of mechanical stimuli in scaffolds for bone tissue engineering, J Biomech, 41, pp. 1005-1014, (2008)

[49]

Goodship A.E., Kenwright J., The influence of induced micromovement upon the healing of experimental tibial fractures, J Bone Joint Surg Br, 67, pp. 650-655, (1985)

[50]

Leucht P., Kim J.B., Wazen R., Et al., Effect of mechanical stimuli on skeletal regeneration around implants, Bone, 40, pp. 919-930, (2007)

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