Cardiovascular Disease Risk in Young People with Type 1 Diabetes

被引：0
作者：
Janet K. Snell-Bergeon
Kristen Nadeau
机构：
[1] University of Colorado Anschutz Medical Center,Barbara Davis Center for Childhood Diabetes
[2] University of Colorado Anschutz Medical Center,Colorado School of Public Health
[3] University of Colorado Anschutz Medical Center,Department of Pediatric Endocrinology
来源：
Journal of Cardiovascular Translational Research | 2012年 / 5卷
关键词：
Type 1 diabetes; Cardiovascular disease; Subclinical atherosclerosis; Adolescents; Insulin resistance; Inflammation; Cardiovascular function; Carotid intima-media thickness; Physical activity; Hypertension; Nephropathy; Cardiovascular mortality;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Cardiovascular disease (CVD) is the most frequent cause of death in people with type 1 diabetes (T1D), despite modern advances in glycemic control and CVD risk factor modification. CVD risk identification is essential in this high-risk population, yet remains poorly understood. This review discusses the risk factors for CVD in young people with T1D, including hyperglycemia, traditional CVD risk factors (dyslipidemia, smoking, physical activity, hypertension), as well as novel risk factors such as insulin resistance, inflammation, and hypoglycemia. We present evidence that adverse changes in cardiovascular function, arterial compliance, and atherosclerosis are present even during adolescence in people with T1D, highlighting the need for earlier intervention. The methods for investigating cardiovascular risk are discussed and reviewed. Finally, we discuss the observational studies and clinical trials which have thus far attempted to elucidate the best targets for early intervention in order to reduce the burden of CVD in people with T1D.
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页码：446 / 462
页数：16
相关论文
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