RNA processing pathways in amyotrophic lateral sclerosis

被引：0
作者：
Marka van Blitterswijk
John E. Landers
机构：
[1] University of Massachusetts Medical School,Department of Neurology
[2] University Medical Center Utrecht,Department of Neurology
来源：
neurogenetics | 2010年 / 11卷
关键词：
Amyotrophic lateral sclerosis; Mutation; RNA processing; Transcription; Splicing;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
RNA processing is a tightly regulated, highly complex pathway which includes RNA transcription, pre-mRNA splicing, editing, transportation, translation, and degradation of RNA. Over the past few years, several RNA processing genes have been shown to be mutated or genetically associated with amyotrophic lateral sclerosis (ALS), including the RNA-binding proteins TDP-43 and FUS/TLS. These findings suggest that RNA processing may represent a common pathogenic mechanism involved in development of ALS. In this review, we will discuss six ALS-related, RNA processing genes including their discovery, function, and commonalities.
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页码：275 / 290
页数：15
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