Effect of CYP2C19, UGT1A8, and UGT2B7 on valproic acid clearance in children with epilepsy: a population pharmacokinetic model

[1] Begley CE(2015)The direct cost of epilepsy in the United States: a systematic review of estimates Epilepsia 56 1376-1387

[2] Durgin TL(2002)Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy CNS Drugs 16 669-694

[3] Loscher W(2015)Clinical significance of CYP2C9-status guided valproic acid therapy in children Epilepsia 56 849-855

[4] Budi T(2014)Soybean greatly reduces valproic acid plasma concentrations: a food-drug interaction study Sci Rep 4 4362-83

[5] Toth K(2015)Population pharmacokinetics of valproic acid in adult Chinese epileptic patients and its application in an individualized dosage regimen Ther Drug Monit 37 76-317

[6] Nagy A(2015)A population pharmacokinetic model of valproic acid in pediatric patients with epilepsy: a non-linear pharmacokinetic model based on protein-binding saturation Clin Pharmacokinet 54 305-1688

[7] Marahatta A(2012)Population pharmacokinetics of valproic acid in pediatric patients with epilepsy: considerations for dosing spinal muscular atrophy patients J Clin Pharmacol 52 1676-1684

[8] Bhandary B(2007)Population pharmacokinetics of valproate in Chinese children with epilepsy Acta Pharmacol Sin 28 1677-425

[9] Jeong SK(2002)Population pharmacokinetics of intravenous valproic acid in Korean patients J Clin Pharm Ther 27 419-1193

[10] Kim HR(2015)Determination of the optimal concentration of valproic acid in patients with epilepsy: a population pharmacokinetic-pharmacodynamic analysis PLoS One 10 e0141266-520

[1] Begley CE(2015)The direct cost of epilepsy in the United States: a systematic review of estimates Epilepsia 56 1376-1387

[2] Durgin TL(2002)Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy CNS Drugs 16 669-694

[3] Loscher W(2015)Clinical significance of CYP2C9-status guided valproic acid therapy in children Epilepsia 56 849-855

[4] Budi T(2014)Soybean greatly reduces valproic acid plasma concentrations: a food-drug interaction study Sci Rep 4 4362-83

[5] Toth K(2015)Population pharmacokinetics of valproic acid in adult Chinese epileptic patients and its application in an individualized dosage regimen Ther Drug Monit 37 76-317

[6] Nagy A(2015)A population pharmacokinetic model of valproic acid in pediatric patients with epilepsy: a non-linear pharmacokinetic model based on protein-binding saturation Clin Pharmacokinet 54 305-1688

[7] Marahatta A(2012)Population pharmacokinetics of valproic acid in pediatric patients with epilepsy: considerations for dosing spinal muscular atrophy patients J Clin Pharmacol 52 1676-1684

[8] Bhandary B(2007)Population pharmacokinetics of valproate in Chinese children with epilepsy Acta Pharmacol Sin 28 1677-425

[9] Jeong SK(2002)Population pharmacokinetics of intravenous valproic acid in Korean patients J Clin Pharm Ther 27 419-1193

[10] Kim HR(2015)Determination of the optimal concentration of valproic acid in patients with epilepsy: a population pharmacokinetic-pharmacodynamic analysis PLoS One 10 e0141266-520