Skin Wound Healing Potential and Antioxidant Effect of Hyaluronic Acid Extracted from Mytilus galloprovincialis and Crassostrea gigas

被引：0

作者：

Nawzet Bouriga

Sami Mili

Wafa Rjiba Bahri

Bayrem Jammeli

Mossadok Ben-Attia

Jean-Pierre Quignard

Monia Trabelsi

机构：

[1] Biology Department,Ecology, Biology and Physiology Laboratory of Aquatic Organisms

[2] Faculty of Sciences of Tunis,University of Carthage

[3] University Tunis el Manar,Laboratory of Biodiversity, Biotechnology and Climate change LR11ES09, Faculty of Sciences of Tunis

[4] Higher Institute of Fisheries and Aquaculture of Bizerte,LR13AGR02: ADIPARA Lab, Higher School of Agriculture of Mateur, BP 7030

[5] Research Unit: Exploitation of Aquatic Environments,Laboratory of Biosurveillance of the Environment, Faculty of Science of Bizerte

[6] University Tunis el Manar,Ichtyology Laboratory

[7] University of Carthage,undefined

[8] University of Carthage,undefined

[9] University of Montpellier II,undefined

[10] Sciences et Techniques Languedoc,undefined

[11] Place Eugene Bataillon,undefined

来源：

Pharmaceutical Chemistry Journal | 2022年 / 56卷

关键词：

bivalve molluscs; wound healing; hyaluronan; purification; antioxidant activity; Mediterranean sea;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

This research work was devoted to studying the ability of hyaluronic acid (HA) to treat skin wounds in rats. HA, an immune-neutral polysaccharide, is widespread in the human body as it is necessary for several tissues and cellular functions and has been used in the clinical practice for more than three decades. For this purpose, we attempted to obtain and enrich HA-containing extracts from two species of molluscs collected at Bizerte lagoon, namely Mytilus galloprovincialis and Crassostrea gigas. Then, the wound healing potential of purified HA (hyaluronan) was tested on Wistar rats which were separated into 4 groups: control, treated with a marketed healing cream “Avene Cicalfate”, treated with HA isolated from M. galloprovincialis, and treated with HA isolated from C. gigas. After anesthesia, rats were submitted to back skin lesions (diameter 2 cm) and then treated daily until recovery. During the experiment, variation of the wound area was monitored. Results showed that the obtained net yield of HA was 3.8 mg/g dry weight and 1.9 mg/g dry weight for M. galloprovincialis and C. gigas respectively. Morphological analysis demonstrated that HA significantly accelerated wound repair through reepithelization. The mean wound surface was completely absent after 15 days of treatment with C. gigas hyaluronan. Based on these findings, it appears that mollusc HA has an obvious healing activity completely in accordance with its recognized effectiveness in dermo-cosmetology.

引用

页码：381 / 386

页数：5