Pluripotent Stem Cells and Skeletal Regeneration—Promise and Potential

被引:0
|
作者
Joy Y. Wu
机构
[1] Stanford University School of Medicine,Division of Endocrinology
来源
Current Osteoporosis Reports | 2015年 / 13卷
关键词
Bone; Skeleton regeneration; Stem cells;
D O I
暂无
中图分类号
学科分类号
摘要
The bone is a regenerative tissue, capable of healing itself after fractures. However, some circumstances such as critical-size defects, malformations, and tumor destruction may exceed the skeleton’s capacity for self-repair. In addition, bone mass and strength decline with age, leading to an increase in fragility fractures. Therefore, the ability to generate large numbers of patient-specific osteoblasts would have enormous clinical implications for the treatment of skeletal defects and diseases. This review will highlight recent advances in the derivation of pluripotent stem cells, and in their directed differentiation towards bone-forming osteoblasts.
引用
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页码:342 / 350
页数:8
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