Peptide Derivatives of Antibiotics Tylosin and Desmycosin, Protein Synthesis Inhibitors

被引：0
|
作者：
N. V. Sumbatyan
G. A. Korshunova
A. A. Bogdanov
机构：
[1] Lomonosov Moscow State University,Faculty of Chemistry
[2] Lomonosov Moscow State University,Belozersky Institute of Physico
来源：
Biochemistry (Moscow) | 2003年 / 68卷
关键词：
antibiotics; macrolides; tylosin; desmycosin; peptide derivatives of macrolides; ribosomal tunnel;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Biologically active peptide derivatives of 16-member macrolide antibiotics were synthesized as potential probes for the investigation of nascent peptide chain topography in the ribosomal exit tunnel. The tylosin and desmycosin aldehyde groups at the C6 position of the lactone ring were modified by the aminooxyacetyl-L-alanyl-L-alanine methyl ester.
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页码：1156 / 1158
页数：2
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