Reduction of NgR in perforant path decreases amyloid-β peptide production and ameliorates synaptic and cognitive deficits in APP/PS1 mice

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作者
Rong Jiang
Xue-Fei Wu
Bin Wang
Rong-Xiao Guan
Lang-Man Lv
Ai-Ping Li
Lei Lei
Ye Ma
Na Li
Qi-Fa Li
Quan-Hong Ma
Jie Zhao
Shao Li
机构
[1] Dalian Medical University,Liaoning Provincial Key Laboratory of Cerebral Diseases, Department of Physiology, College of Basic Medical Sciences
[2] Dalian Medical University,National
[3] Soochow University,Local Joint Engineering Research Center for Drug Research and Development (R&D) of Neurodegenerative Diseases
关键词
Alzheimer’s disease; Nogo receptor; Perforant path; Amyloid precursor protein (APP); Amyloid beta; Rho/ROCK signaling pathway;
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